Research progress on non-O157 Shiga toxin-producing Escherichia coli
BA Peng-bin1,2, MENG Qiong1, BAI Xiang-ning1, AI Yong-xun2, XIONG Yan-wen1
1.State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China;
2.Medical College, Jianghan University, Wuhan 430056, China
Shiga toxin-producing Escherichia coli (STEC) is a subset of E. coli which can produce one or more Shiga toxins. Until now, more than 400 STEC serotypes were identified, but O157:H7 serotype is still the most prevalent. In recent years, more and more sporadic infections and outbreaks caused by non-O157 STEC strains were reported worldwide. There is no an effective method to identify all of heterogeneous non-O157 STEC strains, so the situation of non-O157 STEC infection may be under-estimated. This review is aimed to address the etiology, pathogenesis, epidemiology, diagnosis, treatment and prevention of non-O157 STEC.
巴鹏斌, 孟琼, 白向宁, 艾永循, 熊衍文. 非O157产志贺毒素大肠埃希菌研究进展[J]. 中国人兽共患病学报, 2017, 33(2): 156-162.
BA Peng-bin, MENG Qiong, BAI Xiang-ning, AI Yong-xun, XIONG Yan-wen. Research progress on non-O157 Shiga toxin-producing Escherichia coli. Chinese Journal of Zoonoses, 2017, 33(2): 156-162.
[1] Bryan A, Youngster I, McAdam AJ. Shiga toxin producing Escherichia coli [J]. Clin Lab Med, 2015, 35(2): 247-272. doi:10.1016/j.cll.2015.02.004
[2] Frank C, Werber D, Cramer JP, et al. Epidemic profile of Shiga-toxin-producing Escherichia coli O104:H4 outbreak in Germany[J]. N Engl J Med, 2011, 365(19): 1771-1780. doi:10.1056/NEJMoa1106483
[3] Bielaszewska M, Mellmann A, Zhang W, et al. Characterisation of the Escherichia coli strain associated with an outbreak of haemolytic uraemic syndrome in Germany, 2011: a microbiological study[J]. Lancet Infect Dis, 2011, 11(9): 671-676. doi:10.1016/S1473-3099(11)70165-7
[4] Blanco M, Blanco JE, Mora A, et al. Serotypes, virulence genes, and intimin types of Shiga toxin (verotoxin)-producing Escherichia coli isolates from cattle in Spain and identification of a new intimin variant gene (eae-xi)[J]. J Clin Microbiol, 2004, 42(2): 645-651. doi:10.1128/JCM.42.2.645-651.2004
[5] Bettelheim KA. The non-O157 Shiga-toxigenic (Verocytotoxigenic) Escherichia coli ; under-rated pathogens[J]. Crit Rev Microbiol, 2007, 33(1): 67-87. doi:10.1080/10408410601172172
[6] Karmali MA, Mascarenhas M, Shen S, et al. Association of genomic O island 122 of Escherichia coli EDL 933 with verocytotoxin-producing Escherichia coli seropathotypes that are linked to epidemic and/or serious disease[J]. J Clin Microbiol, 2003, 41(11): 4930-4940. doi:10.1128/JCM.41.11.4930-4940.2003
[7] Vidovic S, Korber DR. Escherichia coli O157: Insights into the adaptive stress physiology and the influence of stressors on epidemiology and ecology of this human pathogen[J]. Crit Rev Microbiol, 2016, 42(1): 83-93. doi:10.3109/1040841X.2014.889654
[8] Croxen MA, Finlay BB. Molecular mechanisms of Escherichia coli pathogenicity[J]. Nat Rev Microbiol, 2010, 8(1): 26-38. doi:10.1038/nrmicro2265
[9] Bergan J, Dyve Lingelem AB, Simm R, et al. Shiga toxins[J]. Toxicon, 2012, 60(6): 1085-1107. doi:10.1016/j.toxicon.2012.07.016
[10] Scheutz F, Teel LD, Beutin L, et al. Multicenter evaluation of a sequence-based protocol for subtyping Shiga toxins and standardizing Stx nomenclature[J]. J Clin Microbiol, 2012, 50(9): 2951-2963. doi:10.1128/JCM.00860-12
[11] Lim JY, Yoon J, Hovde CJ. A brief overview of Escherichia coli O157∶H7 and its plasmid O157[J]. J Microbiol Biotechnol, 2010, 20(1): 5-14. doi:10.4014/jmb.0908.08007
[12] Brooks JT, Sowers EG, Wells JG, et al. Non-O157 Shiga toxin-producing Escherichia coli infections in the United States, 1983-2002[J]. J Infect Dis, 2005, 192(8): 1422-1429. doi:10.1086/466536
[13] Bettelheim KA. The non-O157 shiga-toxigenic (verocytotoxigenic) Escherichia coli ; under-rated pathogens[J]. Crit Rev Microbiol, 2007, 33(1): 67-87. doi:10.1080/10408410601172172
[14] Smith JL, Fratamico PM, Gunther NW 4th. Shiga toxin-producing Escherichia coli [J]. Adv Appl Microbiol, 2014, 86: 145-197. doi:10.1016/B978-0-12-800262-9.00003-2
[15] Eggert M, Stuber E, Heurich M, et al. Detection and characterization of Shiga toxin-producing Escherichia coli in faeces and lymphatic tissue of free-ranging deer[J]. Epidemiol Infect, 2012, 141(02): 251-259. doi:10.1017/S0950268812000246
[16] Ghanbarpour R, Daneshdoost S. Identification of shiga toxin and intimin coding genes in Escherichia coli isolates from pigeons (Columba livia) in relation to phylotypes and antibiotic resistance patterns[J]. Trop Anim Health Prod, 2012, 44(2): 307-312. doi:10.1007/s11250-011-0021-0
[17] Tseng M, Fratamico PM, Manning SD, et al. Shiga toxin-producing Escherichia coli in swine: the public health perspective[J]. Anim Health Res Rev, 2014, 15(1): 63-75. doi:10.1017/S1466252313000170
[18] Meng Q, Bai X, Zhao A, at al. Characterization of Shiga toxin-producing Escherichia coli isolated from healthy pigs in China[J]. BMC Microbiol, 2014, 14: 5. doi:10.1186/1471-2180-14-5
[19] Bai X, Zhao A, Lan R, et al. Shiga toxin-producing Escherichia coli in yaks ( Bos grunniens ) from the Qinghai-Tibetan Plateau, China[J]. PLoS One, 2013, 8(6): e65537. doi:10.1371/journal.pone.0065537
[20] Bai X, Wang H, Xin Y, et al. Prevalence and characteristics of Shiga toxin-producing Escherichia coli isolated from retail raw meats in China[J]. Int J Food Microbiol, 2015, 200: 31-38. doi:10.1016/j.ijfoodmicro.2015.01.018
[21] Bai X, Zhang W, Tang X, et al. Shiga toxin-producing Escherichia coli in Plateau Pika (Ochotona curzoniae) on the Qinghai-Tibetan Plateau, China[J]. Front Microbiol, 2016, 7: 375. doi:10.3389/fmicb.2016.00375
[22] Buchholz U, Bernard H, Werber D, et al. German outbreak of Escherichia coli O104:H4 associated with sprouts[J]. N Engl J Med, 2011, 365(19): 1763-1770. doi:10.1056/NEJMoa1106482
[23] King LA, Nogareda F, Weill FX, et al. Outbreak of Shiga toxin-producing Escherichia coli O104:H4 associated with organic fenugreek sprouts, France, June 2011[J]. Clin Infect Dis, 2012, 54(11): 1588-1594. doi:10.1093/cid/cis255
[24] Terajima J, Iyoda S, Ohnishi M, et al. Shiga toxin (verotoxin)-producing Escherichia coli in Japan[J]. Microbiol Spectr, 2014, 2(5).
[25] Hirvonen JJ, Siitonen A, Kaukoranta SS. Usability and performance of CHROMagar STEC medium in detection of Shiga toxin-producing Escherichia coli strains[J]. J Clin Microbiol, 2012, 50(11): 3586-3590. doi:10.1128/JCM.01754-12
[26] Hauswaldt S, Nitschke M, Sayk F, et al. Lessons learned from outbreaks of Shiga toxin producing Escherichia coli [J]. Curr Infect Dis Rep, 2013,15(1): 4-9. doi:10.1007/s11908-012-0302-4
[27] Girard MP, Steele D, Chaignat CL, et al. A review of vaccine research and development: human enteric infections[J]. Vaccine, 2006, 24(15): 2732-2750. doi:10.1016/j.vaccine.2005.10.014
2017, Vol. 33 
