Investigation and analysis of the first cases of human infection with avian influenza A(H9N2) virus in Chengdu, China
YANG Lei1, DU Xun-bo1, ZHANG Xiao-chun1, YUE Yong1, WENG Gui-wu1, ZAN Yu2, HAN De-lin1
1.Chengdu Center for Disease Control and Prevention, Chengdu 610041, China; 2.Shuangliu Center for Disease Control and Prevention, Chengdu 610200, China
Abstract：We summarized the epidemiological investigation results of the first case of human infection with avian influenza A(H9N2) virus in Chengdu, China, in order to provide references for dealing with similar diseases scientifically in the future. The methods of field epidemiology and laboratory testing were used to collect the H9N2 case’s clinical and epidemiological data, as well as collect and test the samples of the H9N2 case and the relevant environment, so that the possible sources of infection, the epidemiological characteristics and clinical features could be analyzed. Results showed that the H9N2 case contacted with poultry within 10 days before the onset of illness and the H9N2 virus nucleic acid was detected in the patient’s specimen by PCR. This case suffered from several chronic diseases for a long time, although active treatments were taken this time, she died soon after onset. Her living environment, the chicken leftovers from cooking, and surrounding poultry markets were polluted by H9 avian influenza virus. Through the investigation, we could deduce that the infection source of this case was the chicken infecting H9N2 viruses from surrounding poultry markets. This would be the first fatality associated with influenza A(H9N2) virus infections in humans.And though avian influenza A(H9N2) virus was low pathogenic, infection could cause severe symptoms or death in people with severe underlying diseases.
杨磊, 杜训波, 张晓春, 岳勇, 翁贵武, 昝宇, 韩德琳. 成都市首例人感染H9N2禽流感病例调查与分析[J]. 中国人兽共患病学报, 2017, 33(3): 245-249.
YANG Lei, DU Xun-bo, ZHANG Xiao-chun, YUE Yong, WENG Gui-wu, ZAN Yu, HAN De-lin. Investigation and analysis of the first cases of human infection with avian influenza A(H9N2) virus in Chengdu, China. Chinese Journal of Zoonoses, 2017, 33(3): 245-249.
[1] CDC. Types of Influenza Viruses[EB/OL]. (2016-09-15)[2017-02-07]. https://www.cdc.gov/flu/ about/viruses/types.htm. [2] National Health and Family Planning Commission of the PRC. Diagnosis and treatment plan of human infection with avian influenza A(H7N9) virus[EB/OL]. (2017-01-25)[2017-02-07]. http://www.nhfpc.gov.cn/yzygj/s3593g/201701/2dbdbc6e 82dd4fdfa57508499f61cdfc.shtml. (in Chinese) 国家卫生计生委. 人感染H7N9禽流感诊疗方案(2017年第1版)[EB/OL]. (2009-05-12)[2016-08-01]. http://www.nhfpc.gov.cn/yzygj/s3593g/201701/2dbdbc6e82dd4fdfa57508499 f61cdfc.shtml. [3] Yuen KY, Chan PKS, Peiris M, et al. Clinical features and rapid viral diagnosis of human disease associated with avian influenza AH5N1 virus[J]. Lancet, 1998, 351: 467-471. [4] Xin L, Shu YL. A potential pandemic influenza virus: H9N2 avian influenza virus[J]. Chin J Exp Clin Virol, 2013, 27(03): 234-235. (in Chinese) 辛丽, 舒跃龙. 潜在的流感大流行病毒:H9N2禽流感病毒[J]. 中华实验和临床病毒学杂志, 2013, 27(3): 234-235. [5] Hu MX, Zhao KF, Zhang WY. Retrospective analysis of a case of influenza A(H9N2) virus infection in Anhui province[J]. Anhui Med J, 2016, 37(2): 214-216. (in Chinese) 胡明霞,赵科伕,张文艳.安徽省1例H9N2流感病例及回顾性分析[J]. 安徽医学, 2016, 37(2): 214-216. [6] Chinese Center for Disease Control and Prevention. Epidemiological investigation plan of human infection with avian influenza A(H7N9) virus[EB/OL]. (2013-06-26)[2017-02-07]. http://www.chinacdc.cn/jkzt/crb/zl/rgrgzbxqlgg/rgrglgyh/201306/P020130626350207588624.pdf. (in Chinese) 中国疾控中心.人感染H7N9禽流感流行病学调查方案[EB/OL]. (2013-06-26)[2017-02-07]. http://www.chinacdc.cn/jkzt/crb/zl/rgrgzbxqlgg/rgrglgyh/201306/P020130626350207588624.pdf. [7] Liu D, Shi W, Gao GF. Poultry carrying H9N2 act as incubators for novel human avian influenza viruses[J]. Lancet, 2014, 383(9920): 869. [8] Guo YJ, Li JG, Cheng XW, et al. Discovery of men infected by avian influenza A( H9N2) virus[J]. Chin J Exp Clin Virol, 1999, 13(2): 105-108. (in Chinese) 郭元吉, 李建国, 程小雯, 等. 禽H9N2亚型流感病毒能感染人的发现[J]. 中华实验和临床病毒学杂志, 1999, 13(2): 105-108. [9] WHO. Monthly risk assessment summary (influenza at the human-animal interface)[EB/OL]. (2017-01-16)[2017-02-07]. http://www.who.int/influenza/human_animal_interface/HAI_Risk_Assessment/en/. [10] Woo PC, Lau SK, Yuen KY. Infectious diseases emerging from Chinese wet-markets: zoonotic origins of severe respiratory viral infections[J]. Curr Opin Infect Dis, 2006, 19: 401-407. doi:10.1097/01.qco.0000244043.08264.fc [11] Li ZW, Liu S, Hou GY, et al. Epidemiological surveys of H9N2 subtype avian influenza in live bird markets in the regions of the Yangtze River Delta and Pearl River Delta in China[J]. Anim Husb Vet Med, 2015, 47(10): 13-17. (in Chinese) 李照伟, 刘朔, 侯广宇, 等.我国长三角和珠三角地区活禽市场H9N2亚型禽流感流行病学调查[J]. 畜牧与兽医, 2015, 47(10): 13-17. [12] Xin L, Bai T, Zhou JF, et al. Serological study of human infection with avian influenza A ( H9N2 ) virus in population with occupational exposure in China[J]. Dis Surveill, 2015, 30(5): 368-371. (in Chinese) 辛丽, 白天, 周剑芳, 等. 中国职业暴露人群感染H9N2禽流感病毒血清学调查[J].疾病监测, 2015, 30(5): 368-371. [13] Wang M, Fu CX, Zheng BJ. Antibodies against H5 and H9 avian influenza among poultry workers in China[J]. N Engl J Med, 2009, 360(24): 2583-2584. doi:10.1056/NEJMc0900358 [14] Huang R, Wang AR, Liu ZH, et al. Seroprevalence of avian influenza H9N2 among poultry workers in Shandong province, China[J]. Eur J Clin Microbiol Infect Dis, 2013, 32(10): 1347-1351. doi:10.1007/s10096-013-1888-7 [15] Wang Q, Ju L, Liu P, et al. Serological and virological surveillance of avian influenza A virus H9N2 subtype in humans and poultry in Shanghai, China, Between 2008 and 2010[J]. Zoonoses Public Hlth, 2015, 62(2): 131-140. doi:10.1111/zph.12133 [16] Chen Y, Zheng Q, Yang K, et al. Serological survey of antibodies to influenza A viruses in a group of people without a history of influenza vaccination[J]. Clin Microbiol Infect, 2011, 17(9): 1347-1349.
2017, Vol. 33 
