First-line drug resistance of Mycobacterium tuberculosis isolated in Southwest China
CHEN Xing1, LI Yu-qing1, WAN Li3, LIU Hai-can2, ZHAO Xiu-qin2, GUAN Cha-xiang3, WAN Kang-lin1, 2, YUAN Xiu-qin1
1. School of Public Health, University of South China, Hengyang 421001, China; 2. State Key Laboratory for Infectious Diseases Prevention and Control,Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China; 3. Department of Physiology, Xiangya Medical School, Central South University, Changsha 410000, China
Abstract：The drug-resistance and its influencing factors of clinical isolates of Mycobacterium tuberculosis (M. tuberculosis) in Southwest China were investigated in this study, for providing the basic scientific reference for the prevention and control of tuberculosis (TB). A total of 500 clinical isolates of M. tuberculosis from the sputum specimens of the patients with TB in 2006—2013 were collected in the four provinces of the southwestern China (Guizhou, Guangxi, Sichuan and Chongqing). The drug susceptibility of the strains to the four drugs was tested with the drug susceptibility test (DST) of the proportion method. Statistical analyses were carried out by using χ2 analysis and logistic regression analysis. Among all the 500 clinical isolates of M. tuberculosis, the percentages of drug resistance to INH, RFP, EMB and SM were 30.40%, 26.00%, 9.80% and 24.40%, respectively. The total drug resistant rate and multi drug-resistant (MDR) rate were 40.60% and 27.20%, respectively. The total drug resistant rate and MDR rate in Guizhou, Sichuan, Guangxi and Chongqing were 64.10% and 46.15%, 59.54% and 51.90%, 28.88% and 14.97%, 20.19% and 3.85%, respectively. There were significant differences (P<0.05) in drug-resistant rate to INH, RFP, EMB, SM, the total drug resistance and MDR in these areas. Logistic regression analysis showed that the influence factors were case types and area (P<0.05). The drug resistance of tuberculosis was very severe in southwest China, especially in Guizhou and Sichuan. For guiding the clinical medication to prevention and control of drug-resistant TB, we should be more attention to the surveillance of drug resistance of M. tuberculosis.
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2017, Vol. 33 
