CUI Xin-guo1, GUO Xiao-fang1, 2, ZHOU Hong-ning1, 2
1.Institution of Pathogens and Vectors, Pu?er Division, Dali University, Pu?er 665000, China; 2.Yunnan Key Laboratory of Arbor Infectious Diseases Prevention and Control Research/ Yunnan Public Health Coordination and Innovation Center and Yunnan Arbor-virus Research Center of Yunnan Institution of Parasitic Diseases, Pu?er 665000, China
Abstract:Dengue fever is an arbovirus disease caused by dengue virus and transmitted by mosquitoes. Dengue fever is widely distributed to tropical and subtropical regions in the world. Human are generally susceptible to dengue virus, its clinical sign and symptom mainly include high fever, muscle and joints pain, and rash etc, and its main laboratory biochemical indicator is associated with leucopenia and thrombocytopenia. Severe dengue fever has a high mortality incidence without timely diagnosis and treatment. Therefore, it is important for early clinical diagnosis dengue virus infectious case and treatment to reduce mortality incidence and prevent from its epidemic outbreak and spread. Normally, the clinical features of dengue patient mainly include symptom, sign and laboratory test. In this paper, commonly clinical feature of dengue patient was reviewed.
基金资助:国家自然科学基金项目(Nos.81160357,30960327,30660160),中英学者基金资助项目(Sino-British fellowship trust in UK,No.313669)和云南公共卫生与疾病防控协同创新中心项目(No.2014YNPHXT03)联合资助
通讯作者:
周红宁,Email:zhouhn66@163.com
引用本文:
崔新国, 郭晓芳, 周红宁. 我国登革热病例临床特征研究进展[J]. 中国人兽共患病学报, 2017, 33(4): 366-371.
CUI Xin-guo, GUO Xiao-fang, ZHOU Hong-ning. Advances in clinical features of dengue fever. Chinese Journal of Zoonoses, 2017, 33(4): 366-371.
[1] Duonga V, Lambrechtsb L, Paul RE, et al. Asymptomatic humans transmit dengue virus to mosquitoes[J]. Proc Natl Acad Sci USA,2015, 112(47):14688-14693. doi:10.1073/pnas.1508114112 [2] Translation by Zhang Y. Dengue: guidelines for diagnosis, treatment, prevention and control. New ed[M].Shanghai: Shanghai Science and Technology Press,2010:27-34.(in Chinese) 张仪 译. 登革:诊断、治疗、预防控制指南.新版[M].上海:上海科学技术出版社,2010:27-34. [3] Rigau-Pérez JG, Clark GG, Gubler DJ, et al. Dengue and dengue haemorrhagic fever[J]. Lancet,1998,352(9132):971-977. [4] Meng FX, Wang YG, Feng L, et al. Prevention and control of Dengue fever and comprehensive control of Aedes in China[J]. Chin J Vector Biol Control,2015,26(1):4-10. doi:10.11853/j.issn.1003.4692.2015.01.002(in Chinese) 孟凤霞,王义冠,冯磊,等. 我国登革热疫情防控与媒介伊蚊的综合治理[J]. 中国媒介生物学及控制杂志,2015,26(1): 4-10. [5] Department of Diseases Control, MOH. Dengue prevention and control manual[S]. 2nd ed.Beijing:People?s Medical Publishing House, 2008:74-78. (in Chinese) 卫生部疾病预防控制局.登革热防治手册[S].2版.北京:人民卫生出版社,2008:74-98. [6] Lambrechts L, Fansiri T, Pongsiri A,et al. Dengue-1 virus clade replacement in Thailand associated with enhanced mosquito transmission[J]. Virol, 2012,86(3):1853-1861. doi:10.1128/JVI.06458-11 [7] Grange L, Simon-Loriere E, Sakuntabhai A, et al. Epidemiological risk factors associated with high global frequency of inapparent dengue virus infections[J]. Front Immunol,2014,5(280):1-9. doi:10.3389/fimmu.2014.00280 [8] Wang J, Hong WX, Zhang FC. Comparative analysis of clinical features of Dengue fever cases of three serotypes in Guangzhou city[J].J Trop Med,2007,7(10):1760-1762. doi:10.3969/j.issn.1009-9727.2007.10.010(in Chinese) 王建,洪文昕,张复春. 广州市三种血清型登革热患者临床特点对比分析[J]. 中国热带医学杂志,2007,7(10):1760-1762. [9] Wu S. The clinical features of 52 cases of dengue fever Analysis[J]. Zhejiang Practic Med,2010,15(5):370-382. doi:10.3969/j.issn.1007-3299.2010.05.015(in Chinese) 吴霜. 52例登革热的临床特征分析[J]. 浙江实用医学,2010,15(5):370-382. [10] Liang WB, Xie WY, Liu YT, et al. Clinical analyzing for 257 Dengue cases in Guangzhou in 2013[J].JETCM, 2014,23(9):1659-1661. doi:10.3969/j.issn.1004-745X.2014.09.031(in Chinese) 梁伟波,谢文源,刘云涛,等. 2013年广州地区257例登革热病例临床分析[J]. 中国中医急症,2014,23(9):1659-1661. [11] Ying RS, Tang XP, Zhang FC, et al. Clinical characteristics of the patients with dengue fever from 2002 to 2006 in Guangzhou[J]. Chin J Exp Clin Virol,2007,21(2):123-125. doi:10.3760/cma.j.issn.1003-9279.2007.02.009(in Chinese) 应若素,唐小平,张复春,等. 广州市2002—2006年登革热病例特征[J].中华实验和临床病毒学杂志,2007,21(2):123-125. [12] Zhang FC, Lu YC, Chen YQ, et al. Clinical and laboratory characteristics of 1 032 patients with dengue fever in Guangzhou from 2002 to 2003[J].Chin Infect Dis,2004,23(2):121-124. doi:10.3760/j.issn:1000-6680.2005.02.015(in Chinese) 张复春,卢业成,陈燕清,等. 2002至2003年广州及周边地区103 2例登革热的临床特征[J].中华传染病杂志,2004,23(2):121-124. [13] Liu MH, Huang SY, Pan C. Clinical analysis of 1 649 patients with dengue fever outbreak in Fuzhou in 1999[J]. Chin J Zoonoses,2002,18(4):132-133. (in Chinese) 柳美华,黄恕英,潘晨. 1999年福州市暴发流行登革热1 649例的临床分析[J].中国人兽共患病学报,2002,18(4):132-133. [14] Zhang XY, Zhang FC, Hu YF, et al. Analysis of clinical and laboratory features with dengue fever patients in Guangzhou in 2010[J].J Practic Med,2011,27(19):3480-3482. doi:10.3969/j.issn.1006-5725.2011.19.011(in Chinese) 张霞意,张复春,胡凤玉,等. 2010 年广州登革热患者临床及实验室特征分析[J]. 实用医学杂志,2011,27,(19):3480-3482. [15] Ying RS, Wang J, Hong WX. Clinical and laboratory features of patients with dengue fever during the outbreak in Guangdong in 2014[J].Chin Infect Dis,2014,32(12):719-723. doi:10.3760/cma.j.issn.1000-6680.2014.12.004(in Chinese) 应若素,王建,洪文昕. 广东省2014年登革热暴发流行的临床和实验室特点[J].中华传染病杂志,2014,32(12):719-723. [16] Zhang H,Zhou YP,Peng HJ, et al. Predictive symptoms and signs of severe dengue disease for patients with dengue fever: a meta-analysis[J]. Biomed Res Int,2014,2014:1-10. doi:10.1155/2014/359308 [17] Nunes PC, Sampaio SA, Rodrigues da Costa N, et al. Dengue severity associated with age and a new lineage of dengue virus-type 2 during an outbreak in Rio De Janeiro, Brazil[J]. Med Virol,2016,88(7):1130-1136. doi:10.1002/jmv.24464 [18] Solomon T, Dung NM, Vaughn DW, et al. Neurological manifestations of dengue infection[J]. Lancet, 2000, 355(9209):1053-1059. doi:10.1016/S0140-6736(00)02036-5 [19] Oliveira DB, Machado G, Freitas Almeida GM, et al. Infection of the central nervous system with dengue virus 3 genotype I causing neurological manifestations in Brazil[J]. Rev Soc Bras Med Trop,2016,49(1):125-129. doi:10.1590/0037-8682-0208-2015 [20] Soares CN, Cabral-Castro MJ, Peralta JM, et al. Meningitis determined by oligosymptomatic dengue virus type 3 infection: report of a case[J]. Int J Infect Dis,2010,14(2):e150-152. doi:10.1016/j.ijid.2009.03.016 [21] The general office of National Health and Family Planning Commission of the People?s Republic of China. Dengue: guidelines for diagnosis and treatment[Z]. 2nd ed.Traditional Chinese Drug Research &Clinical Pharmacology, 2016,27(1):138-142. doi:10.3969/j.issn.1003-9783.2016.01.030(in Chinese) 国家卫生计生委办公厅.登革热诊疗指南[Z].2版.中药新药与临床管理,2016,27(1):138-142. [22] WHO. Dengue haemorrhagic fever: diagnosis, treatment and control[M]. Geneva,WHO press 1986:1-40. [23] Zhang GM, Li C, Zhuo YG, et al. Clinical characteristics and treatment of two cases of Guillain-Barre syndrome following dengue fever[J].J Trop Med,2015,15(11):1517-1519. (in Chinese) 张国明,李踔,卓友光,等.登革热合并吉兰-巴雷综合征2 例临床特征及治疗[J]. 热带医学杂志,2015,15(11):1517-1519. [24] Li JP, Zhang FC, Hong WX, et al. Clinical analysis of dengue fever complicated with multiple organ injury[J].Int J Intern Med,2008,35(6):314-317. (in Chinese) 李剑萍,张复春,洪文昕,等. 登革热并发多器官损害的临床特点分析[J].国际内科学杂志,2008,35(6):314-317. [25] Zou L, Chen SS, Huang ZQ, et al. Clinical characteristics of new cases with dengue fever in Foshan in Guangdong[J].J Trop Med,2015,15(11):1396-1398. doi:10.13604/j.cnki.46-1064/r.2015.11.30(in Chinese) 邹林,陈绍森,黄泽棋,等. 广东佛山地区新发登革热流行的临床特征[J].中国热带医学,2015,15(11):1396-1398. [26] Wang HM, Zhan WX, Chen PS, et al. Retrospective study on clinical characteristics of 643 patients with suspected dengue in Guangzhou[J].J Trop Med,2015,15(10):1396-1398. (in Chinese) 王慧敏,詹伟祥,陈培松,等. 广州市区疑似登革热643 例临床特征分析[J].热带医学杂志,2015,15(10):1396-1398. [27] Onder H. Letter regarding article,unusual presentation of dengue fever cerebral venous thrombosis[J].J Clin Diagn Res, 2016 ,10(8):TL01. doi:10.7860/JCDR/2016/19191.8241 [28] Deshwal R,Qureshi MI,Singh R. Clinical and laboratory Profile of dengue fever[J].J Assoc Physicians India, 2015,63(12):30-32. [29] Pothapregada S,Kamalakannan B,Thulasingham M, et al. Clinically profiling pediatric patients with dengue[J].J Glob Infect Dis,2016,8(3):115-120. doi:10.4103/0974-777X.188596 [30] Nimmannitya S. Clinical spectrum and management of dengue haemorrhagic fever[J]. Southeast Asian J Trop Med Public Health,1987,18(3):392-397. [31] Deng QQ, Liu Q. Analysis of epidemiology and laboratory characteristics of dengue fever patients in Guangzhou in 2014[J].Int J Lab Med,2016,37(1):121-123. doi:10.3969/j.issn.1673-4130.2016.01.058(in Chinese) 邓勤勤,刘 琦.2014年广州登革热患者流行病学及实验室特征分析[J]. 国际检验医学杂志,2016,37(1):121-123. [32] Chen YQ, Tang XP, Guan YJ, et al. Analysis of Clinical laboratory diagnosis in 484 Dengue fever patients[J]. Int J Lab Med,2008,31(1):82-85. doi:10.3321/j.issn:1009-9158.2008.01.019(in Chinese) 陈燕清,唐小平,关玉娟,等. 484例登革热临床实验诊断的分析[J].中华检验医学杂志,2008,31(1):82-85. [33] Herbinger KH, Hanus I, Beissner M, et al. Lymphocytosis and lymphopenia induced by imported infectious diseases:a controlled cross-sectional study of 17 229 diseased german travelers returning from the tropics and subtropics[J]. Am J Trop Med Hyg,2016,94(6):1385-1391. doi:10.4269/ajtmh.15-0920 [34] Luo C, Ai XY, Fan HM, et al. The clinical characteristics of dengue fever complicated with liver damage[J].J Trop Med,2015,15(11):1459-1501. (in Chinese) 罗纯,艾香英,范慧敏,等.登革热并发肝损害的临床特征[J]. 热带医学杂志,2015,15(11):1459-1501. [35] Chen QL, Xiong T, Feng LM, et al. Changes of partial clinical laboratory indicators in patients with dengue fever in the early stage[J].Sichuang J Physiologic Sci,2015,37(2):71-73. (in Chinese) 陈玲群,熊铁,冯丽梅,等.登革热急性发热期部分实验室指标变化规律的研究[J].四川生理科学杂志,2015,37(2):71-73. [36] Xian ZR, Chen QX, Zhan YC. The relationship between changes of cardiac enzymes in patients with dengue fever and other laboratory markers [J].Guangdong Med J,2015,36(16):2565-2567. (in Chinese) 冼中任,陈秋霞,詹铀超. 登革热患者心肌酶变化及与其他实验室指标的关系[J]. 广东医学,2015,36(16):2565-2567. [37] Zhang QH, Ye XY, Chen HT, et al. The clinical features of dengue fever complicated with liver damage [J].Chin J Integrated Traditional Western Med Liver Dis,2008,18(6):374-375. doi:10.3969/j.issn.1005-0264.2008.06.025(in Chinese) 张全会,叶晓燕,陈红涛,等. 登革热并发肝损害的临床特点[J].中西医结合肝病杂志,2008,18(6):374-375. [38] Zhang JS, Cai WP, Wang J, et al. Analysis of 13 dengue fever patients with viral myocarditis [J].Infect Dis Info,2008,21(1):54-55. doi:10.3969/j.issn.1007-8134.2008.01.018(in Chinese) 张坚生,蔡伟平,王建,等. 登革热并发病毒性心肌炎13例分析[J]. 传染病信息,2008,21(1):54-55. [39] Cavailler P, Tarantola A, Leo YS, et al. Early diagnosis of dengue disease severity in a resource-limited Asian country[J]. BMC Infect Dis,2016, 16:512. doi:10.1186/s12879-016-1849-8 [40] Kuna A,Bykowska M,Kulawiak N, et al. Clinico-laboratory profile of dengue patients returning from tropical areas to Poland during 2010-15[J]. J Vector Borne Dis,2016,53(3):234-239. [41] Tan LM, Wang JP, Ceng FS, et al. Analysis of clinical characteristics of the 12 cases of neonatal dengue fever in Guangzhou in 2014 and literatures in review[J]. Chin J Pediatr,2015,53(12):943-947. doi:10.3760/cma.j.issn.0578-1310.2015.12.015(in Chinese) 谭丽梅,王俊平,曾凡森,等.2014年广州市新生儿登革热12例临床特点分析并文献复习[J].中华儿科杂志,2015,53(12):943-947. [42] Lu HJ, Zhou ZY, Li GM, et al. The clinical characteristics of dengue patients with brain disease[J].Guangdong Med J,2016,37(14):2145-2147. (in Chinese) 卢鸿基,周子懿,李国铭,等.登革热脑病临床特征分析[J]. 广东医学,2016,37(14):2145-2147. [43] Pan YJ, Zhang Y, Deng XL. Clinical characteristic of severe dengue patients with lung lesion [J]. Mod Hospital,2016,16(4):501-503. doi:10.3969/j.issn.1671-332X.2016.04.013(in Chinese) 潘越峻,张媛,邓西龙.重症登革热合并肺部改变患者临床特征分析[J].现代医院,2016,16(4):501-503.