Abstract：The bacterium Streptomyces peucetius produces doxorubicin and daunorubicin, and the two widely used anticancer antibiotics. Two open reading frames, drrA and drrB, were proposed to encode for an ABC (ATP-binding cassette) type of permease that carries out export of the antibiotic ABC (ATP binding cassette)-type transporter for the exportation of these two antibiotics. In this paper, the structure, expression and interaction of DrrA and DrrB protein and the research progress of the assembly and multi drug efflux function of DrrAB are briefly reviewed.
冯振月, 刘德福, 刘硕, 王丽姿, 崔玉东. 链霉菌DrrAB外排系统的研究进展[J]. 中国人兽共患病学报, 2017, 33(5): 454-458.
FENG Zhen-yue, LIU De-fu, LIU Shuo, WANG Li-zi, CUI Yu-dong. Progress in research of the DrrAB efflux system of Streptomyces peucetius. Chinese Journal of Zoonoses, 2017, 33(5): 454-458.
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2017, Vol. 33 
