Abstract：To investigate the epidemiological and clinical characteristics of emerging infectious gnathostomiasis in China, a retrospective analysis was performed on 16 cases of gnathostomiasis found during 2009-2011. Patients consisted of 11 women and 5 men. The median age was 48 years (ranging from 27 to 68years). Eleven out of 16 patients (68.8%) had history of ingesting raw or undercooked freshwater fish. The main manifestation of patients was cutaneous form. Clinical symptoms included migratory swelling, creeping eruption and skin rash. Among them, 43.8%(7/16) of patients presented eosinophilia. The results of serological tests showed all patients were Gnathostoma-specific IgG positive by dot immunogold fitration assay (DIGFA) and 5 cases (31.2%) were positive by immunoblot for detection of specific 24-kDa protein band reaction. The median time from onset of symptoms to diagnosis was 12 months with a range of 2 weeks to 3 years. A total of 11 patients were treated with albendazole and/or ivermectin. Ten patients did not relapse post treatment. During 2009-2011, the number of patients with gnathostomiasis significantly increased due to consumption of raw or under-cooked loaches and swamp eels. Serological test was a necessary tool to support clinical diagnosis while gnathostomiasis commonly presented complex symptoms. Ivermectin and albendazole were effective to treat gnathostomiasis.
马安, 王越, 刘晓龙, 干小仙. 颚口线虫病16例流行病学及临床特征分析[J]. 中国人兽共患病学报, 2017, 33(11): 1048-1051.
MA An, WANG Yue, LIU Xiao-long, GAN Xiao-xian. Epidemiological and clinical characteristics of 16 cases of gnathostomiasis. Chinese Journal of Zoonoses, 2017, 33(11): 1048-1051.
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2017, Vol. 33 
