Research advances on the virulence factors of Corynebacterium pseudotuberculosis
ZHOU Zuo-yong1,2, LI He-xian1, YANG Hao-yue1, WANG Zhi-ying1,2
1.Department of Veterinary Medicine, Rongchang Campus of Southwest University, Rongchang 402460, China; 2. Veterinary Science Engineering Research Center of Chongqing, Rongchang 402460, China
Abstract:Zoonotic pathogen Corynebacterium pseudotuberculosis is the etiological agent of Caseous lymphadenitis (CLA), a chronic infectious disease throughout almost the whole world, which is extremely difficult to control. The pathogenesis of C. pseudotuberculosis is closely related to its virulence factors. In this paper, the virulence factors of C. pseudotuberculosis are reviewed, and it is proposed to further identify and analyze the roles and correlations of other different virulence factors in the pathogenesis of C. pseudotuberculosis infection, which is important for understanding the pathogenic mechanism and identify candidate vaccine of C. pseudotuberculosis.
周作勇, 李和贤, 杨浩钺, 王芝英. 伪结核棒状杆菌毒力因子的研究进展[J]. 中国人兽共患病学报, 2017, 33(12): 1115-1119.
ZHOU Zuo-yong, LI He-xian, YANG Hao-yue, WANG Zhi-ying. Research advances on the virulence factors of Corynebacterium pseudotuberculosis. Chinese Journal of Zoonoses, 2017, 33(12): 1115-1119.
[1] Dorella FA, Pacheco LG, Oliveira SC, et al. Corynebacterium pseudotuberculosis : microbiology, biochemical properties, pathogenesis and molecular studies of virulence[J]. Vet Res, 2006, 37(2): 201-218. doi:10.1051/vetres: 2005056 [2] Abebe D, Sisay TT. Determination of Corynebacterium pseudotuberculosis prevalence and antimicrobial susceptibility pattern of isolates from lymph nodes of sheep and goats at an organic export abattoir, Modjo, Ethiopia[J]. Lett Appl Microbiol, 2015, 61(5): 469-476. doi:10.1111/lam.12482 [3] Baird GJ, Fontaine MC. Corynebacterium pseudotuberculosis and its role in ovine caseous lymphadenitis[J]. J Comp Pathol, 2007, 137(4): 179-210. doi:10.1016/j.jcpa.2007.07.002 [4] Oliveira M, Barroco C, Mottola C, et al. First report of Corynebacterium pseudotuberculosis from caseous lymphadenitis lesions in Black Alentejano pig (Sus scrofa domesticus)[J]. BMC Vet Res, 2014, 10: 218. doi:10.1186/s12917-014-0218-3 [5] Zhou ZY, Li HX, Zhang MS, et al. Genome sequence of Corynebacterium pseudotuberculosis strain XH02 isolated from a boer goat in Xuanhan, China[J]. Genome Announc, 2016, 4(6): e01329-16. doi:10.1128/genomeA.01329-16 [6] Zhang MS, Li HX, Zhou ZY. Diagnosis and drug susceptibility test of Corynebacterium pseudotuberculosis isolated from goat in Dazhou area, Sichuan[J]. Chin J Vet Med, 2015, 51(12): 54-56. (in Chinese) 张梦思,李和贤,周作勇.四川达州地区山羊伪结核棒状杆菌病的诊断及药敏试验[J]. 中国兽医杂志,2015, 51(12): 54-56. [7] Bastos BL, Dias Portela RW, Dorella FA, et al. Corynebacterium pseudotuberculosis : Immunological responses in animal models and zoonotic potential[J]. J Clin Cell Immunol, 2012, 1(S4): 5. [8] D’Afonseca V, Moraes PM, Dorella FA, et al. A description of genes of Corynebacterium pseudotuberculosis useful in diagnostics and vaccine applications[J]. Genet Mol Res, 2008, 7(1): 252-260. [9] Ghannoum MA. Potential role of phospholipases in virulence and fungal pathogenesis[J]. Clin Microbiol Rev, 2000, 13(1): 122-143. doi:10.1128/CMR.13.1.122-143.2000 [10] Schmiel DH, Miller VL. Bacterial phospholipases and pathogenesis[J]. Microbes Infect, 1999, 1(13): 1103-1112. [11] Carne HR. The toxin of Corynebacterium ovis [J]. J Pathol Bacteriol, 1940, 51(2): 199-212. [12] Songer JG, Beckenbach K, Marshall MM, et al. Biochemical and genetic characterization of Corynebacterium pseudotuberculosis [J]. Am J Vet Res, 1988, 49(2): 223-226. [13] Santana-Jorge KT, Santos TM, Tartaglia NR, et al. Putative virulence factors of Corynebacterium pseudotuberculosis FRC41: vaccine potential and protein expression[J]. Microb Cell Fact, 2016, 15: 83. doi:10.1186/s12934-016-0479-6 [14] Hodgson AL, Bird P, Nisbet IT. Cloning, nucleotide sequence, and expression in Escherichia coli of the phospholipase D gene from Corynebacterium pseudotuberculosis [J]. J Bacteriol, 1990, 172(3): 1256-1261. [15] Yozwiak ML, Songer JG. Effect of Corynebacterium pseudotuberculosis phospholipase D on viability and chemotactic responses of ovine neutrophils[J]. Am J Vet Res, 1993, 54(3): 392-397. [16] Mcnamara PJ, Bradley GA, Songer JG. Targeted mutagenesis of the phospholipase D gene results in decreased virulence of Corynebacterium pseudotuberculosis [J]. Mol Microbiol, 1994, 12(6): 921-930. [17] Hodgson AL, Carter K, Tachedjian M, et al. Efficacy of an ovine caseous lymphadenitis vaccine formulated using a genetically inactive form of the Corynebacterium pseudotuberculosis phospholipase D[J]. Vaccine, 1999, 17(7/8): 802-808. [18] De Rose R, Tennent J, Mcwaters P, et al. Efficacy of DNA vaccination by different routes of immunisation in sheep[J]. Vet Immunol Immunopathol, 2002, 90(1/2): 55-63. [19] Hodgson AL, Tachedjian M, Corner LA, et al. Protection of sheep against caseous lymphadenitis by use of a single oral dose of live recombinant Corynebacterium pseudotuberculosis [J]. Infect Immun, 1994, 62(12): 5275-5280. [20] Combs DJ, Lu Z. Sphingomyelinase D inhibits store-operated Ca 2+ entry in T lymphocytes by suppressing ORAI current[J]. J Gen Physiol, 2015, 146(2): 161-172. doi:10.1085/jgp.201511359 [21] Pacheco LG, Pena RR, Castro TL, et al. Multiplex PCR assay for identification of Corynebacterium pseudotuberculosis from pure cultures and for rapid detection of this pathogen in clinical samples[J]. J Med Microbiol, 2007, 56(Pt 4): 480-486. doi:10.1099/jmm.0.46997-0 [22] Williamson LH. Caseous lymphadenitis in small ruminants[J]. Vet Clin North Am Food Anim Pract, 2001, 17(2): 359-371. [23] Muckle CA, Gyles CL. Relation of lipid content and exotoxin production to virulence of Corynebacterium pseudotuberculosis in mice[J]. Am J Vet Res, 1983, 44(6): 1149-1153. [24] Kazmierczak MJ, Wiedmann M, Boor KJ. Alternative sigma factors and their roles in bacterial virulence[J]. Microbiol Mol Biol Rev, 2005, 69(4): 527-543. doi:10.1128/MMBR.69.4.527-543.2005 [25] Staron A, Sofia HJ, Dietrich S, et al. The third pillar of bacterial signal transduction: classification of the extracytoplasmic function (ECF) sigma factor protein family[J]. Mol Microbiol, 2009, 74(3): 557-581. doi:10.1111/j.1365-2958 [26] Fontan PA, Aris V, Alvarez ME, et al. Mycobacterium tuberculosis sigma factor E regulon modulates the host inflammatory response[J]. J Infect Dis, 2008, 198(6): 877-885. doi:10.1086/591098 [27] Voskuil MI, Bartek IL, Visconti K, et al. The response of mycobacterium tuberculosis to reactive oxygen and nitrogen species[J]. Front Microbiol, 2011, 2: 105. doi:10.3389/fmicb.2011.00105 [28] Pacheco LG, Castro TL, Carvalho RD, et al. A role for Sigma factor sigma(E) in Corynebacterium pseudotuberculosis resistance to nitric oxide/peroxide stress[J]. Front Microbiol, 2012, 3: 126. doi:10.3389/fmicb.2012.00126 [29] Moraes PM, Seyffert N, Silva WM, et al. Characterization of the Opp peptide transporter of Corynebacterium pseudotuberculosis and its role in virulence and pathogenicity[J]. Biomed Res Int, 2014, 2014: 489782. doi:10.1155/2014/489782 [30] Monnet V. Bacterial oligopeptide-binding proteins[J]. Cell Mol Life Sci, 2003, 60(10): 2100-2114. doi:10.1007/s00018-003-3054-3 [31] Braibant M, Gilot P, Content J. The ATP binding cassette (ABC) transport systems of Mycobacterium tuberculosis [J]. FEMS Microbiol Rev, 2000, 24(4): 449-467. [32] Quiocho FA, Ledvina PS. Atomic structure and specificity of bacterial periplasmic receptors for active transport and chemotaxis: variation of common themes[J]. Mol Microbiol, 1996, 20(1): 17-25. [33] Billington SJ, Esmay PA, Songer JG, et al. Identification and role in virulence of putative iron acquisition genes from Corynebacterium pseudotuberculosis [J]. FEMS Microbiol Lett, 2002, 208(1): 41-45. [34] Aquino DSMC, Gouveia GV, Krewer CC, et al. Distribution of PLD and FagA, B, C and D genes in Corynebacterium pseudotuberculosis isolates from sheep and goats with caseus lymphadenitis[J]. Genet Mol Biol, 2013, 36(2): 265-268. doi:10.1590/S1415-47572013005000013 [35] Simmons CP, Hodgson AL, Strugnell RA. Attenuation and vaccine potential of aroQ mutants of Corynebacterium pseudotuberculosis [J]. Infect Immun, 1997, 65(8): 3048-3056. [36] Trost E, Ott L, Schneider J, et al. The complete genome sequence of Corynebacterium pseudotuberculosis FRC41 isolated from a 12-year-old girl with necrotizing lymphadenitis reveals insights into gene-regulatory networks contributing to virulence[J]. BMC Genomics, 2010, 11: 728. doi:10.1186/1471-2164-11-728 [37] Rogers EA, Das A, Ton-That H. Adhesion by pathogenic corynebacteria[J]. Adv Exp Med Biol, 2011, 715: 91-103. doi:10.1007/978-94-007-0940-9_6 [38] Kim S, Oh DB, Kang HA, et al. Features and applications of bacterial sialidases[J]. Appl Microbiol Biotechnol, 2011, 91(1): 1-15. doi:10.1007/s00253-011-3307-2 [39] Kim S, Oh DB, Kwon O, et al. Identification and functional characterization of the NanH extracellular sialidase from Corynebacterium diphtheriae [J]. J Biochem, 2010, 147(4): 523-533. doi:10.1093/jb/mvp198 [40] Walburger A, Koul A, Ferrari G, et al. Protein kinase G from pathogenic mycobacteria promotes survival within macrophages[J]. Science, 2004, 304(5678): 1800-1804. doi:10.1126/science.1099384 [41] Warner DF, Mizrahi V. The survival kit of Mycobacterium tuberculosis [J]. Nat Med, 2007, 13(3): 282-284. doi:10.1038/nm0307-282 [42] Dussurget O, Stewart G, Neyrolles O, et al. Role of Mycobacterium tuberculosis copper-zinc superoxide dismutase[J]. Infect Immun, 2001, 69(1): 529-533. doi:10.1128/IAI.69.1.529-533.2001 [43] Piddington DL, Fang FC, Laessig T, et al. Cu, Zn superoxide dismutase of Mycobacterium tuberculosis contributes to survival in activated macrophages that are generating an oxidative burst[J]. Infect Immun, 2001, 69(8): 4980-4987.doi:10.1128/IAI.69.8.4980-4987.2001 [44] Silva WM, Dorella FA, Soares SC, et al. A shift in the virulence potential of Corynebacterium pseudotuberculosis biovar ovis after passage in a murine host demonstrated through comparative proteomics[J].BMC Microbiol, 2017, 17(1): 55. doi:10.1186/s12866-017-0925-6 [45] Carvalho DM, de Sa PH, Castro TL, et al. Reference genes for RT-qPCR studies in Corynebacterium pseudotuberculosis identified through analysis of RNA-seq data[J]. Antonie Van Leeuwenhoek, 2014, 106(4): 605-614. doi:10.1007/s10482-014-0231-3