Abstract:Leptospirosis has long been a sporadic zoonosis in Liping County. This study aims to explore the risk factors of leptospirosis infection in general population, and the role rodents play in transmission by an expanded investigation of two deceased cases. Serology survey and demographic investigation were carried out among the general population of two epidemic areas where two deseased cases had been reported, and one extended area where no leptospirosis cases had been diagnosed. Local rodents’ kidney samples were collected for Leptospira isolation. In total 44 people (23.4%) tested positive by microscopic agglutination test (MAT) for four strains of Leptospira. Seropositive rate of the extended area was significantly higher (53.3%, 24/45) than epidemic area (14.0%, 20/143). Positive rate increased with age. Other factors such as occupation, gender showed no significance. The proportion of Apodemus agrarius in the captured rodents and the total germ-carrying rates showed no significant difference in two areas. Long-term rodent carrier surveillance is critical to provide valuable information and locate high risk areas, facilitating prophylactic measures. Vaccination was recommended in high risk areas if economical feasibility and demand were proved.
黄荷, 刘英, 李世军, 姚光海, 梁文琴, 邹志霆. 贵州省黎平县钩端螺旋体病危险因素调查[J]. 中国人兽共患病学报, 2017, 33(12): 1136-1143.
HUANG He, LIU Ying, LI Shi-jun, YAO Guang-hai, LIANG Wen-qin, ZOU Zhi-ting. Risk factors of leptospirosis in Liping County,Guizhou Province, China—an expanded survey in general population and rodents. Chinese Journal of Zoonoses, 2017, 33(12): 1136-1143.
[1] News O. Leptospirosis: an emerging public health problem[Z]. Geneva: WHO. 2011, 86(6): 45-50
[2] Li S, Wang D, Zhang C, et al. Source tracking of human leptospirosis: serotyping and genotyping of Leptospira isolated from rodents in the epidemic area of Guizhou province, China[J]. BMC Microbiol, 2013, 13: 75. doi:10.1186/1471-2180-13-75
[3] Durski KN, Jancloes M, Chowdhary T, et al. A global, multi-disciplinary, multi-sectorial initiative to combat leptospirosis[J]. GLEAN, 2014, 11(6): 6000-6008. doi:10.3390/ijerph110606000
[4] Gouveia EL, Metcalfe J, De Carvalho ALF, et al. Leptospirosis-associated severe pulmonary hemorrhagic syndrome, Salvador, Brazil[J]. Emerg Infect Dis, 2008, 14(3): 505-508. doi:10.3201/eid1403.071064
[5] Brinkerhoff RJ, Collinge SK, Ray C, et al. Typhoon-related leptospirosis and melioidosis, Taiwan, 2009[J]. Vectorborne Zoonotic Dis, 2011, 10(1): 47-52. doi:10.1089/vbz.2009.0044
[6] Bandara M, Ananda M, Wickramage K, et al. Globalization of leptospirosis through travel and migration[J]. Globalizat Hlth, 2014, 10: 61. doi:10.1186/s12992-014-0061-0
[7] Agampodi SB, Dahanayaka NJ, Bandaranayaka AK, et al. Regional differences of leptospirosis in Sri Lanka: Observations from a flood-associated outbreak in 2011 [J]. PLoS Negl Trop Dis, 2014, 8(1): e2626. doi:10.1371/journal.pntd.0002626
[8] Ke Y, Yongquan J, Yongping L. Epidemiology of leptospirosis in Liping county, Guizhou, 2001-2008[J]. Dis Surveill, 2009, 24(10): 768-769.
[9] Lu DQ, Zhou ZW. Sero-epidemiological survey of leptospirosis in Guizhou Province from 1991 to 1993[J]. Chin J Epidemiol, 1995, 16(1): 55.
[10] Shi MH, Tu QL. A survey of geographic distribution of leptospira in China[J]. Chin J Epidemiol, 1995, 16(5): 259-262.
[11] Diagnostic Criteris for Leptospirosis (WS290-2008)[Z]. 2008
[12] Johnson MAS, Smith H, Joeph P, et al. Environmental exposure and leptospirosis, Peru[J]. Emerg Infect Dis, 2004, 10(6): 1016-1022. doi:10.3201/eid1006.030660
[13] Keenan J, Ervin G, Aung M, et al. Risk factors for clinical leptospirosis from Western Jamaica[J]. Am J Trop Med Hyg, 2010, 83(3): 633-636. doi:10.4269/ajtmh.2010.09-0609
[14] Sakundarno M, Bertolatti D, Maycock B, et al. Risk factors for leptospirosis infection in humans and implications for public health intervention in Indonesia and the Asia-Pacific region[J]. Asia-Pacific J Public Hlth, 2014, 26(1): 15-32. doi:10.1177/1010539513498768
[15] Gancheva GI. Leptospirosis in elderly patients[J]. Brazilian J Infect Dis, 2013, 17(5): 592-595. doi:10.1016/j.bjid.2013.01.012
[16] Levett PN. Leptospirosis[J]. Clin Microbiol, 2001, 14(2): 296-326. doi:10.1128/CMR.14.2.296
[17] Xu FX. Current status and challenges of Leptospira vaccine development in China[J]. Chin Pharmaceut Affairs, 2015, 29(7): 730-733.
[18] Khalili M, Sakhaee E, Aflatoonian MR, et al. Seroprevalence of bovine leptospiral antibodies by microscopic agglutination test in Southeast of Iran[J]. Asian Pacific J Trop Biomed, 2014, 4(5): 354-357. doi:10.12980/APJTB.4.2014C1206
[19] Theuerkauf J, Perez J, Taugamoa A, et al. Leptospirosis risk increases with changes in species composition of rat populations[J]. Die Naturwissenschaften, 2013, 100(4): 385-388. doi:10.1007/s00114-013-1033-6
[20] Bacallao J, Schneider MC, Najera P, et al. Socioeconomic factors and vulnerability to outbreaks of leptospirosis in Nicaragua[J]. Intl J Envir Res Public Hlth, 2014, 11(8): 8301-8318. doi:10.3390/ijerph110808301
[21] Felzemburgh RDM, Ribeiro GS, Costa F, et al. Prospective study of leptospirosis transmission in an urban slum community: role of poor environment in repeated exposures to the Leptospira agent[J]. PLoS Neglected Trop Dis, 2014, 8(5): e2927. doi:10.1371/journal.pntd.0002927