Advance in toxic and pathogenic mechanisms of bacterial hemolysins
MA Bi-shu1, MA Li-na2, LIN Xu-ai3, YAN Jie3
1. Department of Microbiology and Immunology, Haiyuan College of Kunming Medical University, Kunming 650106, China; 2. College of Medical Technology, Gansu Chinese Medical University, Lanzhou 743000, China; 3. Department of Microbiology and Parasitology, School of Medicine, Zhejiang University,Hangzhou 310058, China
Abstract：Many bacterial pathogens can produce hemolysins to lyse erythrocytes, but recent studies revealed that bacterial hemolysins could cause injury and death of many nucleated cells and platelets. According to the difference of molecular structure, cell-binding manner and membrane pore-forming mechanism, most of bacterial hemolysins are classified into the toxins belonging to either repeats in toxin family (RTX) or cholesterol-dependent cytolysin family (CDC). Bacterial hemolysins play important pathogenic roles during infection of bacteria through membrane damage, cell lysis or disruption, ion disequilibrium-associated pathological changes, cell apoptosis or cell necroptosis as well as through TLR2/4-mediated NF-κB, p38MAPK, JNK signaling pathways and NLRs-mediated NLRP3 inflammasomes to cause powerful inflammatory reaction and inflammatory tissue injury.
马碧书, 马丽娜, 林旭瑷, 严杰. 细菌溶血素毒性和致病机制研究进展[J]. 中国人兽共患病学报, 2018, 34(2): 175-181.
MA Bi-shu, MA Li-na, LIN Xu-ai, YAN Jie. Advance in toxic and pathogenic mechanisms of bacterial hemolysins. Chinese Journal of Zoonoses, 2018, 34(2): 175-181.
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