Death pattern and cause analysis in mice after establishment of the liver alveolar hydatid model
WANG Yan1, SU Zheng-ming1, CHEN Qian1, ZHANG Huai1, LI Jiang1, DAI Ping2, ZHANG Shi-jie1
1.Department of Hepatobiliary,the First Affiliated Hospital, Medicine College, Shihezi University,Shihezi 832000,China; 2.Department of Oncology,the First Affiliated Hospital, Medicine College, Shihezi University,Shihezi 832000,China
Abstract：We studied the death pattern and the main causes of death after artificial liver inoculation with alveolar hydatid model, and explored the risk factors and prevention of major complications resulting from death after modeling. The 50 healthy Kunming mice were inoculated with open-staring liver puncture and the physiological changes of the mice were observed dynamically within 15 days after operation. The time and amount of death were recorded, and the causes of death and related factors were analyzed emphatically. On the 15 day after surgery, 19 died; 1 died in the ninth day, and the remaining 18 died within 7 days of the operation. The postoperative death rate began to rise in the second day, and gradually decreased to 1 after the peak of the 4 th and 5 th days. The main causes of death of the mice after inoculation were closely related to the complications of surgical methods, anaesthesia, infection, antigenicity of vesicle, and liver injury. Effective prevention of these complications is the key to improve the survival rate.
王岩, 苏争明, 陈骞, 张怀, 李江, 代平, 张示杰. 人工建立肝脏泡球蚴模型后小鼠的死亡规律和原因分析[J]. 中国人兽共患病学报, 2018, 34(3): 207-212.
WANG Yan, SU Zheng-ming, CHEN Qian, ZHANG Huai, LI Jiang, DAI Ping, ZHANG Shi-jie. Death pattern and cause analysis in mice after establishment of the liver alveolar hydatid model. Chinese Journal of Zoonoses, 2018, 34(3): 207-212.
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