Characteristics of antigen distribution and histological lesions of Swiss mice by Toxoplasma gondii (TgSheepHn1) isolated from sheep
LU Yao-yao1, ZHAI Shao-hua2, ZHU Zi-fu1, DONG Hui1, WANG Meng-yao1, YANG Yu-rong1
1. College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou 450000, China; 2. College of Animal Medicine, Xinjiang Agricultural University, Urumqi 830052, China
Abstract:We explored the characteristics of antigen distribution and histological lesions of Swiss mice after infected with ToxoDB#9 (TgSheepHn1) Toxoplasma gondii tachyzoties, which was isolated from sheep. The 104 of T. gondii tachyzoties were inoculated to the mice by intraperitoneal. The H&E and IHC were used to analyze the histological lesions and antigen distribution. As a result, the main lesions of dead mice in acute toxoplasmosis were observed in lung, liver, spleen, mesenteric lymph nodes and small intestine, and lesions in other organs were lightly. At the same time, the huge number of antigens distributed in spleen, mesenteric lymph nodes, adrenal, the duct of gallbladder muscular layer in liver, as well as reproductive organ, while it was less in the brain, heart, lung, kidney, small intestine and bladder. Results showed that the tachyzoties of TgSheepHn1 T. gondii have a great damage to the immune system and digestive system of mice, the antigens distributed widely, the reproductive system and immune system are the primary target organs in mice of acute toxoplasmosis.
陆瑶瑶,翟少华,祝子伏,董辉,王梦瑶,杨玉荣. 绵羊弓形虫TgSheepHn1对小鼠的病理损伤及其抗原分布特点[J]. 中国人兽共患病学报, 2018, 34(6): 519-523.
LU Yao-yao, ZHAI Shao-hua, ZHU Zi-fu, DONG Hui, WANG Meng-yao, YANG Yu-rong. Characteristics of antigen distribution and histological lesions of Swiss mice by Toxoplasma gondii (TgSheepHn1) isolated from sheep. Chinese Journal of Zoonoses, 2018, 34(6): 519-523.
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