Prevalence and drug resistance of Salmonella isolated from diarrhea patients in Shenzhen, China
CHEN Jian1, ZHANG Jin-jin1, YANG Hong2, WU Yan-jie2, LUO Yong-yi3, SHEN Hong-wei1
1. Futian District Center for Disease Control and Prevention, Shenzhen 518040, China; 2. Peking University Shenzhen Hospital, Shenzhen 518036, China; 3. School of Public Health, Guangdong Medical College, Dongguan 523808, China
Abstract:We analyzed the prevalence of Salmonella infection and drug resistance of Salmonella strains isolated from diarrheal patients in Shenzhen during 2014 and 2017. The stool samples were collected from patients visiting diarrhea clinics of 3 sentinel hospitals and Salmonella was isolated and identified. The serotype and antibiotic susceptibility testing were performed in these isolates, and also the isolates from inpatients in 7 hospitals. A total of 192 (4.0%) Salmonella isolates were recovered from 4 847 stool samples and the high detection rate was found during May and October. The higher detection rate was observed in the children aged under 5 years old and the age group of 6-17 years, with 6.2% and 5.3%, respectively. Eighteen serotypes were identified in the 192 isolates, with S. typhimurium, 1,4,12:i:- and S. enterica being the most commonly identified serovars. Another 19 strains were nontypeable. In comparison, 20 serotypes were identified in the 77 isolates from inpatients and 3 strains were nontypeable. S. enterica, 1,4,12:i:-, and S. paratyphi A made up 33.8%, 13.0%, and 11.7% of these isolates, respectively. Of the 45 tested strains, the drug resistance to ampicillin, ciprofloxacin, and levofloxacin was more serious than to other drugs. The quinolone-resistant and multi-drug-resistant (MDR) strains have occurred since 2015 and 50.0% of the 10 S. typhimurium isolates was MDR strain. These results indicated that reasonable the using of antibiotics for treatment of diarrhea and long-term surveillance of antibiotic resistance was required.
陈建,张金金,杨虹,吴延杰,罗泳仪,申红卫. 深圳市腹泻患者沙门菌感染状况和耐药性分析[J]. 中国人兽共患病学报, 2018, 34(6): 532-536.
CHEN Jian, ZHANG Jin-jin, YANG Hong, WU Yan-jie, LUO Yong-yi, SHEN Hong-wei. Prevalence and drug resistance of Salmonella isolated from diarrhea patients in Shenzhen, China. Chinese Journal of Zoonoses, 2018, 34(6): 532-536.