Abstract：ATP-binding cassette (ABC) transporters are integral membrane proteins that actively transport molecules across cell membranes. The ABC is a wide variety of physiological processes in all eukaryotic, archaebacterial and eubacterial species. Recent crystal structures of a number of ATPase domains, substrate binding proteins, and full-length transporters have given new insight in the molecular basis of transport. Bioinformatics approaches allow an approximate identification of all ABC transporters in E. coli and their relation to other known transporters. Computational approaches involving modeling and simulation are beginning to yield insight into the dynamics of the transporters. We summarize the function of the known ABC transporters in E. coli and mechanistic insights from structural and computational studies.
冯振月, 刘德福, 崔玉东. 大肠杆菌ABC转运体研究进展[J]. 中国人兽共患病学报, 2018, 34(10): 944-949.
FENG Zhen-yue, LIU De-fu, CUI Yu-dong. Progress on research of ATP-binding cassette transporters in Escherichia coli. Chinese Journal of Zoonoses, 2018, 34(10): 944-949.
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