Abstract:To summarize and analyze the epidemiological characteristics and genotype of the Scrub typhus in Xiamen and establish the control strategy, data on the prevalence of Scrub typhus in Xiamen between 1954 to 2016 has been collected, and field investigation has been conducted to study the prevalence between 2006 to 2016. The genotyping assay on Orientia tsutsugamushi has been performed in the samples collected from both patients and host animal. Results showed that the report on prevalence in Xiamen was began in 1954, in total 950 cases have been documented between 1954 to 2016. The prevalence between 1954 to 1988 was ranging from 0 to 6.75/100 000. Since 1989, Scrub typhus was no longer a notifiable disease, the incidence in last decades demonstrated an elevation trend. The 690 cases were observed between 2006 to 2016. The cases were mainly found in Siming and Huli districts, and the time distribution showed an incidence peak in summer and autumn. As for gender distribution, the male to female ratio was 1.02∶1. Most of the cases were aged between 20 to 65 years old, and the farmers constituted the majority of cases. The host animal in Xiamen was identified as Rattus norvegicus, and the dominant species of vector was Leptotrombidium delicense. The genotyping assay revealed that the dominant genotype was Karp. The nature epidemic focus of Scrub typhus was detected in Xiamen, therefore, the comprehensive control strategy against mite should be implemented.