Abstract：To study strains and case characteristics of NTM lung diseases in patients from Tuberculosis Research Institute of 309 Hospital, and to provide diagnostic ideas for doctors, NTM-positive reports from September 2014 to March 2018 were collected from the Tuberculosis Research Institute of 309 Hospital. According to the Consensus on the Diagnosis and Treatment of Non-tuberculous Mycobacterial Diseases published by Chinese Medical Association in 2012, NTM lung disease group was established, and the strains characteristics of NTM were studied. The paired pulmonary tuberculosis group was established according to the age, sex, geographical location and duration of the NTM lung disease group. The underlying state of the two groups was analysed. Results showed that 108 cases were positive for NTM, and the separation rate was 4.66%. Seventy-two patients with NTM lung disease were confirmed, the separation rate was 3.10%. Mycobacterium intracellulare (33/72, 45.8%), M. chelonae/abscessus (27/72, 37.5%), M. avium (7/72, 9.7%), M. kansasii (3/72, 4.2%), and M. xenopi (2/72, 2.8%) were included. The patients’ average diagnostic time was 27.8±30.8 months, average age was 64.1±18.0 years; the ratio of males to females was 1.88 overall, but 0.79 in the <60 age group. All the patients in the >80 age group were male, and 11/13 patients were of M. chelonae/abscessus. The underlying incidence of chronic respiratory diseases in patients with NTM lung disease was higher than that of patients with pulmonary tuberculosis, the difference was statistically significant (χ2=4.141, P=0.042). The underlying incidence of bronchiectasis was significantly higher in female NTM lung diseases than that in male patients (χ2=10.277, P=0.006). The mean age of patients with M. chelonae/abscessus lung diseases was 75.2±14.8, which was significantly different (χ2=14.832, P=0.011) from that of patients with M. intracellulare lung disease which was 59.9±17.0. In conclusion, the main pathogens of NTM lung disease in North China and Northeast China are M. intracellulare and M. chelonae/abscessus. The incidence of NTM lung disease increases with age after 40 years old. M. chelonae/abscessus is the most common pathogen after 80 years old. The female patients are young, indicating bronchiectasis is a predisposing factor. NTM lung disease has long diagnosis duration, and mycobacterial nucleic acid test can significantly improve the diagnostic efficiency.
杨栗坤, 曹彦, 曹艳龙, 孙雯娜, 贺熊, 王心静, 王仲元. 结核病专科非结核分枝杆菌肺病菌种分布及病例特点研究[J]. 中国人兽共患病学报, 2018, 34(12): 1137-1141.
YANG Li-kun, CAO Yan, CAO Yan-long, SUN Wen-na, HE Xiong, WANG Xin-jing, WANG Zhong-yuan. Strains and case characteristics of non-tuberculous mycobacterium lung diseases in tuberculosis special department. Chinese Journal of Zoonoses, 2018, 34(12): 1137-1141.
2018, Vol. 34 
