Abstract：Osteoarticular brucellosis is the most common presentation of human disease in the world. There are three most common forms of osteoarticular involvement are peripheral arthritis, sacroiliitis, and spondylitis. Brucella abortus induces bone damage through diverse mechanisms in which TNF-a and RANKL modulator of bone homeostasis are involved. These processes are driven by inflammatory cells, like macrophages, neutrophils, Th17 CD4C T, and T cells. These bacteria inhibit bone matrix deposition by osteoblasts and modify the phenotype of those cells to produce matrix metalloproteinases (MMPs) and cytokine secretion, contributing to bone matrix degradation. Finally, the molecular mechanisms of osteoarticular brucellosis discovered that how the interaction between B. abortus and osteoarticular cells may play an important role in producing damage in joint and bone.
梁晨, 魏伟, 梁秀文, 德恩金, 王立军. 骨关节布鲁氏菌病的研究进展[J]. 中国人兽共患病学报, 2018, 34(12): 1147-1150.
LIANG Chen, WEI Wei, LIANG Xiu-wen, DE En-jin, WANG Li-jun. Research progress of osteoarticular involvement with brucellosis. Chinese Journal of Zoonoses, 2018, 34(12): 1147-1150.
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2018, Vol. 34 
