棘球蚴(包虫)病疫苗研究进展

doi:10.3969/j.issn.1002-2694.2018.00.223

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摘要棘球蚴病是由棘球属绦虫的幼虫寄生于动物(包括人)体内而引起的一类古老疾病,其中细粒棘球蚴病和多房棘球蚴病严重阻碍着畜牧业的发展和人类身体健康,造成了巨大的经济损失。棘球蚴病的有效防治需要抗棘球蚴药物和疫苗以及其他措施的综合实施。虽然一些抗棘球蚴药物作为疫病防控的重要手段已被应用,但化学药物存在耐药性、药物残留、环境污染等问题,而疫苗因具有安全、无残留、动物无休药期、符合“预防为主,治疗为辅”的方针等优点,如今得到愈来愈广泛地研究和应用,并得到了长足的发展和突破。本文对棘球蚴病不同类型疫苗的研究进展做一综述,旨在对棘球蚴病疫苗的研制和开发有更加全面系统的了解和展望。

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	朱国强
	闫鸿斌
	李立
	贾万忠

关键词 ：棘球蚴病, 疫苗, Eg95蛋白, 基因工程, 研究进展

Abstract：Echinococcosis is a kind of age-old disease in humans and animals caused by the larval stage of the genus Echinococcus, of which cystic echinococcosis and alverolar echinococcosis are seriously hindering the development of animal husbandry and human health, and have caused huge economic losses. The effective prevention of echinococcosis depends on anti-echinococcosis drugs, vaccines and implementation of other comprehensive measures. Although some anti-echinococcosis drugs have been applied as an important means of disease prevention and control, chemical drugs may cause drug resistance, drug residue, environmental pollution and other problems. However, vaccines have the advantages of safety, no residue or withdrawal period, and adherence to the policy of prevention first being worth a pound of cure. Therefore, they are being studied and used more and more widely nowadays, and great development and breakthrough has been made. In this paper, advances in research on different types of vaccines against echinococcosis were reviewed with the aim of more deep insights and visions in the development of vaccines against echinococcosis.

Key words： echinococcosis vaccine Eg95 protein gene engineering research advance

收稿日期: 2018-03-14

PACS:

R383.3

基金资助:国家重点研发计划(No.2017YFD0501301)、国家重点基础研究发展计划(973计划)(No.2015CB150300)和甘肃省科技重大专项(No.1203NKDA039)联合资助

通讯作者: 贾万忠,Email:jiawanzhong@caas.cn;ORCID:0000-0002-0801-7478

引用本文:

朱国强, 闫鸿斌, 李立, 贾万忠. 棘球蚴(包虫)病疫苗研究进展[J]. 中国人兽共患病学报, 2019, 35(1): 59-65. ZHU Guo-qiang, YAN Hong-bin, LI Li, JIA Wan-zhong. Advances in research on vaccines against echinococcosis. Chinese Journal of Zoonoses, 2019, 35(1): 59-65.

链接本文:

http://www.rsghb.cn/CN/10.3969/j.issn.1002-2694.2018.00.223 或 http://www.rsghb.cn/CN/Y2019/V35/I1/59

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