Abstract：Zika virus (ZIKV) is a mosquito-borne flavivirus which can cause neonatal microcephaly, intrauterine growth retardation and fetal spontaneous abortion. Interferon λ (IFN-λ) released from placenta primary human trophoblast cells and interferon-stimulated genes (ISGs) induced by IFN-λ can establish antiviral status in cells and protect fetuses from Zika virus infection. Besides, the protection of IFN-λ is gestational stage-dependent, and it does not work during early pregnancy. In this paper, the study on mechanism of IFN-λ resistance against Zika virus are reviewed in order to provide references for further understanding of the pathogenic mechanism and immune prevention of Zika virus.
王晶晶, 曹阳青, 陈金铃. Ⅲ型干扰素抵抗寨卡病毒感染导致不良妊娠的机制[J]. 中国人兽共患病学报, 2019, 35(2): 153-157.
WANG Jing-jing, CAO Yang-qing, CHEN Jin-ling. Mechanism of type III interferon resistance to adverse pregnancy induced by Zika virus infection. Chinese Journal of Zoonoses, 2019, 35(2): 153-157.
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2019, Vol. 35 
