Epidemiological survey of hepatitis E virus infection in voluntary blood donors in Guangzhou
YOU Qing-zhu1, HUANG Jie-ting2, XU Ru2, WANG Min2, LIAO Qiao2, SHAN Zhen-gang2, RONG Xia2, FU Yong-shui1, 2
1. Department of Transfusion Medicine, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, Guangdong 510515, China; 2. Guangzhou Blood Center, Guangzhou, Guangdong 510095, China
Abstract:To investigate the prevalence of hepatitis E virus (HEV) infection among voluntary blood donors in Guangzhou. Blood samples from 5 552 blood donors were collected from April 2017 to April 2018 at the Guangzhou Blood Center and were tested for anti-HEV IgG antibody (HEV IgG), anti-HEV IgM antibody (HEV IgM) and HEV antigen (HEV Ag) by enzyme linked immunosorbent assay (ELISA). The association of age, gender, ethnicity, occupation and ALT with HEV IgG and IgM were analyzed by Chi-square test. Multivariate logistic regression analysis was applied to identify the independent risk factors of HEV infection. The positive rates of HEV IgG, IgM and HEV Ag were 20.05% (1 113/5 552), 0.76% (42/5 552) and 0.04% (2/5 552), respectively. Age and ethnicity were independent risk factors for HEV IgG and HEV IgM. The rate of HEV antibody increased significantly with age (IgG OR=1.089, 95%CI: 1.080-1.098, P<0.001; IgM OR=1.055, 95%CI: 1.028-1.084, P<0.001). Donors who were Zhuang minority (32.69%, 7.69%) showed higher anti-HEV than those who were Han ethnicity (19.89%, 0.70%), and the difference was statistically significant (IgG OR=2.052, 95%CI: 1.103-3.819, P=0.023; IgM OR=12.029, 95%CI: 4.067-35.580, P<0.001). In addition, we found that occupation was an independent risk factor for HEV infection, while students showed the lowest anti-HEV rate. The results indicate that the positive rate of HEV antibody among blood donors in Guangzhou is high, and the infection status differs in different populations. Our study provides basic data for the estimation of risk of transfusion-transmitted HEV.
尤庆柱, 黄杰庭, 许茹, 王敏, 廖峭, 单振刚, 戎霞, 付涌水. 广州地区无偿献血者戊型肝炎病毒感染流行病学调查[J]. 中国人兽共患病学报, 2019, 35(4): 363-368.
YOU Qing-zhu, HUANG Jie-ting, XU Ru, WANG Min, LIAO Qiao, SHAN Zhen-gang, RONG Xia, FU Yong-shui. Epidemiological survey of hepatitis E virus infection in voluntary blood donors in Guangzhou. Chinese Journal of Zoonoses, 2019, 35(4): 363-368.