Abstract：Mycoplasma pneumoniae colonizes the respiratory tract by the attachment organelle, leading to community-acquired pneumonia and other diseases. The attachment organelle consists of two parts: the surface structure and the internal structure. The surface structure is responsible for the binding of M. pneumoniae to the host cell surface, including P1 adhesin, P30 adhesin, P40 and P90. The internal structure is divided into the translucent area and the internal core. Its function includes the formation and maintenance of the attachment organelle as well as the generation and transmission of force. The translucent area is responsible for transferring the force generated by the bowl / wheel complex to paired plates. The internal core consists of three parts: a terminal button, a pair of thin and thick plates, and a bowl/wheel complex. The terminal button consists of HMW3 and P65, determining the gliding direction of the M. pneumoniae. The paired plates consist of the thin plate and the thick plate, which act as scaffold of the attachment organelle. The thin plate features regular hexagonal lattice, composed of HMW1 and CpsG. The thick plate is made of HMW2. The bowl/wheel complex consists of P24, P41, P200, TopJ, Lon, and MPN387. It connects the attachment organelle with the rest of M. pneumoniae and is responsible for the generation or transmission of the force. This article systematically reviews the structure and function of the attachment organelles of M. pneumoniae.
倪珊珊, 薛冠华, 李少丽, 闫超, 孙红妹. 肺炎支原体黏附细胞器的结构与功能[J]. 中国人兽共患病学报, 2019, 35(9): 831-836.
NI Shan-shan,XUE Guan-hua,LI Shao-li,YAN Chao,SUN Hong-mei. Structure and function of attachment organelle in Mycoplasma pneumoniae. Chinese Journal of Zoonoses, 2019, 35(9): 831-836.
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