In vitro anti-tuberculosis activity of the extracts of the Fissistigma cavaleriei root
ZHOU Lei1, 2, AN Ting-ting1, ZHAO Xiu-qin2, XU Dong-lei2, JIANG Yi2, WANG Rui-bai2, WAN Kang-lin2, YANG Zai-chang1
1. College of Pharmacy, Guizhou University, Guiyang 550004, China; 2. State Key Laboratory for Infections Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Centre for Disease Control and Prevention, Beijing 102206, China
Abstract：In order to explore the anti-tuberculosis activity of the extracts of Fissistigma cavaleriei root. Components extracted from the root of Fissistigma cavaleriei by the bioactivity-guided isolation method were tested by in vitro Alarmar-Blue drug sensitivity test of mycobacteria. Three components were separated and purified, in which component 1 and 2 could effectively inhibit the growth of the rifampicin-resistant and multi-drug resistant Mycobacteria strains. The anti-tuberculosis activity of component 2 was higher than that of other components, with the MIC value of 3/4 multi-drug resistant strains lower than 40 μg/mL. Under the current severe situation of the prevalence of drug-resistant tuberculosis, the extracts of Fissistigma cavaleriei have potential in the drug development of mono- and multidrug-resistant tuberculosis. Its effective components and the mechanism of anti-tuberculosis need further study.
周蕾, 安婷婷, 赵秀芹, 徐冬蕾, 蒋毅, 王瑞白, 万康林, 杨再昌. 独山瓜馥木总生物碱抗结核活性初探[J]. 中国人兽共患病学报, 2020, 36(6): 487-490.
ZHOU Lei, AN Ting-ting, ZHAO Xiu-qin, XU Dong-lei, JIANG Yi, WANG Rui-bai, WAN Kang-lin, YANG Zai-chang. In vitro anti-tuberculosis activity of the extracts of the Fissistigma cavaleriei root. Chinese Journal of Zoonoses, 2020, 36(6): 487-490.
