National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention; Chinese Center for Tropical Diseases Research; WHO Collaborating Center of Tropical Diseases; National Center for International Research on Tropical Diseases, Ministry of Science and Technology; Key Laboratory of Parasite and Vector Biology, Ministry of Health, Shanghai 200025, China
Abstract：Aptamers are synthetic single-stranded DNA or RNA oligonucleotides obtained by in vitro screening with systematic evolution of ligands by exponential enrichment. Aptamers are capable of binding viruses, bacteria, parasites and other small molecular targets with high affinity and specificity. Compared with antibodies, aptamers have advantages of no immunogenicity, uncomplicated preparation, straight forward batch production, smooth modification, stable performance and economical price, which possesses crucial application prospects in the field of disease diagnosis and treatment. Aptamers targeting Plasmodium, Trypanosome and Leishmania were chiefly reviewed in this artice provide new thoughts for the detection and control of parasitic diseases.
杨帆, 李石柱, 秦志强. 靶向寄生虫的核酸适配体应用研究进展[J]. 中国人兽共患病学报, 2020, 36(8): 665-671.
YANG Fan, LI Shi-zhu, QIN Zhi-qiang. Research progress on aptamers targeting parasites. Chinese Journal of Zoonoses, 2020, 36(8): 665-671.
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