Advances in oxazolidinone drug linezolid resistance gene optrA
LIU Bao-guang1, 2, HE Dan-dan3, BAI Ming1, 2, CHEN Yi-heng2, WANG Bao-ying1, 2, LI Yu-cheng1, 2, HU Gong-zheng3, MIAO Ming-san1, XU Er-ping2
1. Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou 450046, China; 2. Key Laboratory for Modern Research on Zhongjing’s Herbal Formulae of Henan Province, Zhengzhou 450046, China; 3. College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou 450002, China
Abstract：Antibiotics play an important role in the prevention and treatment of diseases, however, the problem of bacterial resistance has become increasingly serious, aggravating the difficulty of clinical treatment of diseases, and posing a potential threat to human public security. Oxazolidinones are mainly used for severe infections caused by gram-positive bacteria, especially for infections caused by multi-drug resistant bacteria, such as MRSA. In 2015, optrA was first discovered by Chinese scholars, with a gene encoding oxazolidinone resistance existing on both plasmids and chromosomes, but mostly on plasmids. At present, drug resistance gene optrA has been reported in enterococcus, staphylococcus squirrel and streptococcus, which indicates that this gene has a strong ability to spread across bacterias, so the prevalence and spread of optrA gene should be paid great attention. This paper reviews the research progress of optrA to provide references for the rational use of drugs, detection of drug-resistant strains and elucidating the transmission mechanism of drug resistance.
刘保光, 贺丹丹, 白明, 陈毅恒, 汪保英, 栗俞程, 胡功政, 苗明三, 许二平. 恶唑烷酮类药物利奈唑胺耐药基因optrA研究进展[J]. 中国人兽共患病学报, 2020, 36(8): 672-677.
LIU Bao-guang, HE Dan-dan, BAI Ming, CHEN Yi-heng, WANG Bao-ying, LI Yu-cheng, HU Gong-zheng, MIAO Ming-san, XU Er-ping. Advances in oxazolidinone drug linezolid resistance gene optrA. Chinese Journal of Zoonoses, 2020, 36(8): 672-677.
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2020, Vol. 36 
