Molecular transmission of HIV-1 resistant strains among HIV-1 individuals before antiretroviral therapy in the Hebei Province
LIU Meng1, XING Hui2, ZHANG Yu-qi1, LI Yan1, WANG Ying-ying1, AN Ning1, LU Xin-li1
1. Department of AIDS Research, Hebei Key Laboratory of Pathogen and Epidemiology of Infectious Disease, Hebei Provincial Center for Disease Control and Prevention, Shijiazhuang 050021, China; 2. State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention (NCAIDS), Chinese Center for Disease Control and Prevention,Beijing 102206,China;
Abstract:To investigate the epidemic trend of HIV-1 resistant strains among HIV-1 individuals before antiretroviral therapy in Hebei Province. HIV-1 pol gene was amplified and sequenced using in-house method. Then, HIV-1 molecular transmission network was constructed and gene distance was calculated using TN93 model. The results indicated that a total of 17 HIV-1-infected individuals occurred drug resistance mutations, with the overall resistant rate of 6.16% (17/276). The resistant rate of NNRTI was 4.35% (12/276), followed by PI (1.09%, 3/276), NRTI (0.36%, 1/276), and NNRTI and PI (0.36%, 1/276). Multivariate Logistic regression analysis revealed that age and subtype were the effecting factors for HIV-1 drug resistance mutations. Although the resistant rate of HIV-1 in CRF07_BC (2.44%) was significant lower than CRF01_AE (8.03%) and B (3.70%), more molecular transmission networks were found in HIV-1 CRF07_BC strains. In conclusion, the resistant rate of HIV-1 before treatment in Hebei Province was relatively high, and HIV-1 drug resistance should be timely monitored.
刘萌, 邢辉, 张玉琪, 李岩, 王莹莹, 安宁, 路新利. 河北省治疗前人群HIV-1耐药毒株分子传播网络研究[J]. 中国人兽共患病学报, 2020, 36(9): 746-751.
LIU Meng, XING Hui, ZHANG Yu-qi, LI Yan, WANG Ying-ying, AN Ning, LU Xin-li. Molecular transmission of HIV-1 resistant strains among HIV-1 individuals before antiretroviral therapy in the Hebei Province. Chinese Journal of Zoonoses, 2020, 36(9): 746-751.
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