ZHANG Zhan-hong, FENG Hao-jie, JIN Guo-quan, DU Qiu-pei, CUI Yu, FAN Hai-ning
Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hospital of Qinghai University, the key laboratory on enchinococcosis Research of Qinghai Province, Xining 810000,China
Abstract：Ceramides and sphingosine-1-phosphate, biologically active sphingolipids, are not only important components of cell membranes but also play important roles in cell signal transduction as second messengers. Ceramides induce apoptosis and autophagy, and promote inflammatory responses, whereas sphingosine-1-phosphate promotes cell growth, proliferation, and differentiation, and induces immune cell migration. The ceramide signaling pathway, consisting of ceramides, sphingosine-1-phosphate, and key enzymes, is involved in the regulation of pathophysiological processes in many diseases, such as cancer, acute and chronic inflammation, and parasitic diseases. We provide an overview of ceramide signaling pathways and their role in parasitic diseases.
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