Abstract：This study aimed to analyze the pathogenic features of Streptococcus suis serotype 2 (SS2) isolated in Sichuan province between 2006 and 2017. Virulence gene detection, antimicrobial sensitivity analysis and pulsed field gel electrophoresis analysis were performed for 28 strains of SS2 isolated from clinical patients in Sichuan province during 2006-2017. The 28 strains of SS2 were divided into two virulence genotypes: cps2J+/mrp-/sly+/gapdh+/ef+ and cps2J+/mrp+/sly+/gapdh+/ef+. Drug sensitivity test results showed that all strains were susceptible to third and fourth generation cephalosporins, carbapenems, penicillin, levofloxacin, linezolid, vancomycin, chloramphenicol and daptomycin, but resistant to tetracycline. Among the 28 strains of SS2, 26 strains were sensitive to azithromycin, erythromycin and clindamycin, and two strains were resistant to azithromycin, erythromycin and clindamycin. Among the 28 strains of SS2, six PFGE patterns were found, and the sequence similarity was 76%. A total of 23 strains of SS2 had identical PFGE patterns, accounting for 82.14%. The PFGE patterns of 19 strains isolated in 2006 and 2007 were fully consistent. A total of nine strains isolated in 2010-2017 showed six PFGE patterns. From 2006 to 2017, the prevailing strain of SS2 in Sichuan province was highly virulent, had the cps2J+/mrp+/sly+/gapdh+/ef+ genotype and was sensitive to β-lactam drugs. From 2006 to 2007, the clinical isolates of S. suis serotype 2 from different urban areas in Sichuan Province had the same source. The PFGE patterns of strains isolated after 2010 had low similarity.
廖虹瑜, 李文博, 何树森, 罗隆泽, 曾林子. 2006-2017年四川省临床分离猪链球菌2型的病原学特征[J]. 中国人兽共患病学报, 2021, 37(4): 306-310.
LIAO Hong-yu, LI Wen-bo, HE Shu-sen, LUO Long-ze, ZENG Lin-zi. Pathogenic features of Streptococcus suis serotype 2 isolated from clinical patients in Sichuan Province in 2006-2017. Chinese Journal of Zoonoses, 2021, 37(4): 306-310.
