Abstract:Herpesviruses are members of the herpesviruses family. They are a large group of double-stranded DNA viruses that infect a wide range of hosts, including humans and other vertebrates, and mainly affect the skin, mucous membranes and nerve tissues. After infection, the virus cannot be eradicated and can remain recurrently latent in the body. A small number of patients even die after severe infection. Vertebrates and invasive pathogens have evolved over hundreds of millions of years to form highly complex defense mechanisms that protect the body against intracellular pathogens, mainly through MHC molecule-mediated antigen presentation or interferon responses triggered by early viral infection. Faced with the continuous evolution of the animal immune system, the herpesvirus encodes many immune escape proteins and evades the host immune defense through various mechanisms. This article describes recent studies by domestic and foreign researchers examining several human and animal herpesvirus immune escape proteins, classified according to function. This review of herpesvirus proteins may provide a basis for further research on the pathogenic mechanisms and prevention of other herpesviruses in humans and animals.
马宁宁, 刘占, 邓梦梦, 郭子仪, 史志斌, 陈陆. 疱疹病毒免疫逃逸相关蛋白及其作用机制研究进展[J]. 中国人兽共患病学报, 2021, 37(5): 462-466.
MA Ning-ning, LIU Zhan, DENG Meng-meng, SHI Zhi-bin, CHEN Lu. Research advances in herpesvirus immune escape proteins and their mechanisms. Chinese Journal of Zoonoses, 2021, 37(5): 462-466.
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