Distribution and molecular epidemiological characteristics of Yersinia enterocolitica in China
MU Hui1,2, DUAN Ran2, QIN Shuai2, XIAO Meng2, HE Zhao-kai2, LYU Dong-yue2, TANG De-ming2, YANG Jin-chuan2, JING Huai-qi2, ZHAN Jun1, WANG Xin2
1. School of Public Health and Management, Ningxia Medical University, Yinchuan 750004, China; 2. National Institute for communicable disease control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
Abstract：Based on the analysis of the etiology and PFGE molecular types of Yersinia enterocolitica in different regions of China from 1980 to 2019, this study provides a basis for the prevention and control of Yersinia enterocolitica. Methods: A total of 6847 strains of Yersinia enterocolitica isolated from samples from different regions in China were analyzed by pulsed field gel electrophoresis (PFGE). The serotypes, biochemical phenotypes and virulence gene distribution were studied. The results revealed 2047 pathogenic strains and 4800 non-pathogenic strains of Yersinia enterocolitica. Only two serotypes of pathogenic strains, O∶3 accounting for 88.96% (1821/2047) and O∶9 accounting for 11.04% (226/2 047), were identified. The O∶3 serotype was the main pathogenic strain in 18 provinces and autonomous regions, and the O∶9 serotype was the main pathogenic strain in the Ningxia Hui autonomous region. Many serotypes of non-pathogenic bacteria were found to exist and to generally cause more positive biochemical reactions than pathogenic strains. A total of 1821 pathogenic O∶3 strains were divided into 93 PFGE types, distributed in 19 provinces and autonomous regions, among which K6GN11C30021 and K6GN11C30012 were the dominant bands (46.35% and 22.5%, respectively), and 75.38% of the human strains were consistent with those isolated from local animal and food strains. A total of 226 O∶9 pathogenic strains were divided into 14 PFGE types, distributed in 8 provinces and autonomous regions; 77.78% of the human strains were consistent with the local animal and food strains. Therefore, Yersinia enterocolitica is widely distributed and has numerous hosts in China. The pathogenic strains have only two serotypes, whereas the non-pathogenic strains have many serotypes, which may have stronger biochemical metabolic ability and environmental adaptability than the pathogenic strains. The dominant bands of the pathogenic strain PFGE were relatively concentrated and widely distributed in the region. Most of the human strains were consistent with those isolated from local animals and food strains. The risk of human infection through livestock, poultry, food and the external environment should be vigilantly assessed.
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2021, Vol. 37 
