Mechanisms and new vaccine strategies for Streptococcus pneumoniae non-vaccine serotypes
LIU Fu-li1, LI Jia-yin2, HE Ping2, HUA Yun-fen1
1. College of pharmacy, Zhejiang University of Technology, Hangzhou 310014, China; 2. Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
Abstract：Streptococcus pneumoniae is one of the main pathogens causing community-acquired pneumonia and invasive diseases such as meningitis and septicemia. To date, pneumococcal polysaccharide vaccines and pneumococcal conjugate vaccines remain the main methods to prevent Streptococcus pneumoniae infection. However, selective pressure on Streptococcus pneumoniae vaccines targeting specific capsular polysaccharide induces capsule switching to some extent, thus resulting in the production of mutants expressing different capsular antigens, and leading to an increase in non-vaccine types and nonencapsulated Streptococcus pneumoniae. Consequently, the existing vaccines cannot effectively prevent Streptococcus pneumoniae infection. This article focuses on the mechanisms of non-vaccine serotypes of Streptococcus pneumoniae, to provide ideas and strategies for the preparation of new vaccines for Streptococcus pneumoniae.
刘福莉, 李佳茵, 何平, 华允芬. 非疫苗血清型肺炎链球菌发生机制及疫苗新策略[J]. 中国人兽共患病学报, 2021, 37(8): 734-740.
LIU Fu-li, LI Jia-yin, HE Ping, HUA Yun-fen. Mechanisms and new vaccine strategies for Streptococcus pneumoniae non-vaccine serotypes. Chinese Journal of Zoonoses, 2021, 37(8): 734-740.
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2021, Vol. 37 
