Abstract：To observe the efficacy of levofloxacin and moxifloxacin in the treatment of experimental plague in guinea pigs, according to the National Pharmacopoeia of the People's Republic of China, we converted the daily doses of levofloxacin and moxifloxacin into per kg body weight for guinea pigs according to the animal conversion coefficient [levofloxacin 40 mg/(kg·d) and moxifloxacin 32 mg/(kg·d)]. The two drugs were diluted into an aqueous solution in sterilized saline and subcutaneously injected into the experimental animals infected with 141 strains of Yersinia pestis after 24 hours. All experimental animals were given continuous treatment for 9 days, and then the drug administration was stopped. The animals were then sacrificed after 9 days of observation. The animals that died of infection or were sacrificed were dissected, and their organs were subjected to plague bacteriological examination. All experimental animals in the levofloxacin and moxifloxacin treatment groups survived (survival rates of 100%). All surviving animals were sacrificed and dissected, and organs were collected for plague bacteriological examination and culturing. The results were all negative; the experimental animals in the control groups died 3~5 days after infection, and Yersinia pestis was isolated from each animal. Thus, these deaths were considered to be due to Yersinia pestis infection. Both levofloxacin and moxifloxacin were effective in the treatment of guinea pigs infected with Yersinia pestis and thus can substitute for streptomycin in plague prevention and treatment.
李胜, 何建, 辛有全, 杨晓艳, 靳娟, 张琪, 杨建国, 熊浩明, 柏吉祥, 代瑞霞. 左氧氟沙星和莫西沙星治疗豚鼠实验感染鼠疫的研究[J]. 中国人兽共患病学报, 2021, 37(9): 858-860.
LI Sheng, HE Jian, XIN You-quan, YANG Xiao-yan, JIN Juan, ZHANG Qi, YANG Jian-guo, XIONG Hao-ming, BAI Ji-xiang, DAI Rui-xia. Research on levofloxacin and moxifloxacin in the treatment of guinea pigs experimentally infected with Yersinia pestis. Chinese Journal of Zoonoses, 2021, 37(9): 858-860.
2021, Vol. 37 
