Overview of SARS-CoV-2 distribution in human tissues and prolonged shedding in body fluids
ZHANG Yong-jun1,3, LING Hua2,3, CHEN Ai-ping1,3
1. Chongqing Medical and Pharmaceutical College, Chongqing 401331, China; 2. Chongqing Center for Disease Control and Prevention, Chongqing 400042, China; 3. Chongqing Municipal Key Laboratory for High Pathogenic Microbes, Chongqing 400042, China
Abstract:Although the ongoing pandemic coronavirus disease 2019 (COVID-19)caused by SARS-CoV-2 has lasted for over one year, its pathogenesis mechanisms have not been comprehensively elucidated. This review summarized the distribution of viral receptors in human tissues, clinical manifestation of COVID-19 in diverse organs, the broad organotropism of SARS-CoV-2 in multiple organs based on autopsy reports, and evidence concerning virus distribution in human tissues and viral shedding in body fluids. These etiological results will shed new light on the current view of pathogenesis mechanisms of SARS-CoV-2, facilitate in rational choosing of diagnostic specimens and interpretating diagnostic results,promote patient management and treatment, and contribute to combating the pandemic COVID-19 in the near future.
张拥军, 凌华, 陈爱平. SARS-CoV-2的宿主组织分布和体液中排放研究进展[J]. 中国人兽共患病学报, 2021, 37(12): 1118-1122.
ZHANG Yong-jun, LING Hua, CHEN Ai-ping. Overview of SARS-CoV-2 distribution in human tissues and prolonged shedding in body fluids. Chinese Journal of Zoonoses, 2021, 37(12): 1118-1122.
[1] World health organization. WHO coronavirus disease (COVID-19) dashboard[EB/OL].(2021-03-01)[2021-03-01]. https://covid19.who.int/ [2] Harrison AG, Lin T, Wang P.Mechanisms of SARS-CoV-2 transmission and pathogenesis[J]. Trends Immunol,2020,41(12):1100-1115. DOI: 10.1016/j.it.2020.10.004 [3] Fung TS, Liu DX.Similarities and dissimilarities of COVID-19 and other coronavirus diseases[J]. Annu Rev Microbiol,2021,75:19-47. DOI: 10.1146/annurev-micro-110520-023212 [4] Trypsteen W, Van Cleemput J, Snippenberg Wv, et al.On the whereabouts of SARS-CoV-2 in the human body: A systematic review[J]. PLoS Pathog, 2020,16(10): e1009037. DOI: 10.1371/journal. ppat.1009037 [5] Dong M, Zhang J, Ma X, et al.ACE2, TMPRSS2 distribution and extrapulmonary organ injury in patients with COVID-19[J]. Biomed Pharmacother,2020,131:110678. DOI: 10.1016/j.biopha.2020.110678 [6] Bourgonje AR, Abdulle AE, Timens W, et al.Angiotensin-converting enzyme 2 (ACE2), SARS-CoV-2 and the pathophysiology of coronavirus disease 2019 (COVID-19)[J]. J Pathol,2020,251(3):228-248. DOI: 10.1002/path.5471 [7] 中华人民共和国国家卫生健康委员会. 新型冠状病毒肺炎诊疗方案(试行第8版)[EB/OL].(2020-08-19)[2021-01-26].http://www.nhc.gov.cn/xcs/zhengcwj/202008/0a7bdf12bd4b46-e5bd28ca7f9a7f5e5a.shtml [8] Deshmukh V, Motwani R, Kumar A, et al.Histopathological observations in COVID-19: a systematic review[J]. J Clin Pathol,2021,74(2):76-83. DOI: 10.1136/jclinpath-2020-206995 [9] Gavriatopoulou M, Korompoki E, Fotiou D, et al.Organ-specific manifestations of COVID-19 infection[J]. Clin Exp Med,2020,20(4):493-506. DOI: 10.1007/s10238-020-00648-x [10] Synowiec A, Szczepański A, Barreto-Duran E, et al.Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): a systemic infection[J]. Clin Microbiol Rev,2021,34(2):e00133-20. DOI: 10.1128/CMR.00133-20 [11] Carpenito L, D’Ercole M, Porta F, et al. The autopsy at the time of SARS-CoV-2: protocol and lessons[J]. Ann Diagn Pathol,2020,48:151562. DOI: 10.1016/j.anndiagpath.2020.151562 [12] Bullock HA, Goldsmith CS, Miller SE. Best Practices for correctly identifying coronavirus by transmission electron microscopy[J]. Kidney Int,2021,22:S0085-2538(21)00068-5. DOI: 10.1016/j.kint.2021.01.004 [13] Dorward DA, Russell CD, Um IH, et al.Tissue-specific immunopathology in fatal COVID-19[J]. Am J Respir Crit Care Med,2021,203(2):192-201. DOI: 10.1164/rccm.202008-3265OC [14] Schurink B, Roos E, Radonic T, et al.Viral presence and immunopathology in patients with lethal COVID-19: a prospective autopsy cohort study[J]. Lancet Microbe,2020,1(7):e290-e299. DOI: 10.1016/S2666-5247(20)30144-0 [15] Dittmayer C, Meinhardt J, Radbruch H, et al.Why misinterpretation of electron micrographs in SARS-CoV-2-infected tissue goes viral[J]. Lancet,2020, 396(10260):e64-e65. DOI: 10.1016/S0140-6736(20)32079-1 [16] Zapor M.Persistent detection and infectious potential of SARS-CoV-2 virus in clinical specimens from COVID-19 patients[J]. Viruses,2020,12(12):1384. DOI: 10.3390/v12121384 [17] Sun J, Tang X, Bai R, et al. The kinetics of viral load and antibodies to SARS-CoV-2[J]. Clin Microbiol Infect,2020,26(12):1690.e1-1690.e4. DOI: 10.1016/j.cmi.2020.08.043 [18] Wang W, Xu Y, Gao R, et al.Detection of SARS-CoV-2 in different types of clinical specimens[J]. JAMA,2020,323(18):1843-1844. DOI: 10.1001/jama.2020.3786 [19] Wölfel R, Corman VM, Guggemos W, et al.Virological assessment of hospitalized patients with COVID-2019[J]. Nature,2020,581(7809):465-469. DOI: 10.1038/s41586-020-2196-x [20] Chen PF, Yu XX, Liu YP, et al.Virus load and virus shedding of SARS-CoV-2 and their impact on patient outcomes[J]. World J Clin Cases,2020,8(24):6252-6263. DOI: 10.12998/wjcc.v8.i24.6252 [21] Li L, Tan C, Zeng J, et al.Analysis of viral load in different specimen types and serum antibody levels of COVID-19 patients[J]. J Transl Med,2021,19(1):30. DOI: 10.1186/s12967-020-02693-2 [22] Cevik M, Tate M, Lloyd O, et al.SARS-CoV-2, SARS-CoV, and MERS-CoV viral load dynamics, duration of viral shedding, and infectiousness: a systematic review and meta-analysis[J]. Lancet Microbe,2021,2(1):e13-e22. DOI: 10.1016/S2666-5247(20)30172-5