Roles of Schistosoma and associated products in host immune regulation
JIANG Jie1,2, LI Jun-hui1,2, ZHANG Yu1,2, ZHOU Zhao-qin1,2, MING Ying-zi1,2
1. Center for Organ Transplantation, Third Xiangya Hospital, Central South University, Changsha 410013, China; 2. Research Center of National Health Ministry on Transplantation Medicine Engineering and Technology, Third Xiangya Hospital, Central South University, Changsha 410013, China
Abstract:Schistosoma can affect the host immune system by synthesizing, secreting or excreting a variety of immunomodulatory molecules, thereby promoting Th2 immunity and inhibiting Th1/Th17 immune responses. Schistosoma infection can modulate host innate and adaptive immunity, thus enabling escape from the host immune attack and survival for long time periods within the human body. Studies have shown that schistosomiasis may have potential beneficial effects on allergic diseases, autoimmune diseases and allogeneic immunopathology. The mechanism remains unclear but may be related to the immune regulation of schistosomiasis-related molecules. Therefore, further studies on the regulation of Schistosoma-related molecules on the immune system will contribute to the development of new therapeutic strategies for immune-related diseases. This review highlights recent advances in the immune regulation of Schistosoma. Studies on the immunomodulation of Schistosoma and Schistosoma-derived products are expected to provide new therapeutic strategies for allergic diseases, autoimmune diseases and allogeneic immune diseases.
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