Study on drug resistance of Mycobacterium tuberculosis circulating in high altitude area
JIANG Ming-xia1, WANG Zhao-fen2, MA Bin-zhong1, CHAO Xiu-zhen1, WANG Rong1, MA Yong-cheng1, ZHANG Zu-hao2, WANG Chao-cai1, LI Er-chen1, WEI Yu-jia1, LI Bin2
1. Qinghai Center for Disease Control and Prevention,Xining 810007,China; 2. Department of Public Health, Medical School, Qinghai University,Xining 810008,China
Abstract：To study the drug resistance status of 1 531 Mycobacterium tuberculosis (MTB) strains from high altitude area and thus to provide scientific basis for the prevention and control of drug-resistant tuberculosis (DR-TB). 1 531 strains MTB were collected from Qinghai Province, and the proportional method was used to test drug sensitivity of 6 anti-tuberculosis drugs (isoniazid, rifampicin, ethambutol, streptomycin, kanamycin, ofloxacin) commonly used clinically and data were analyzed statistically. The rates fortotal drug resistant(TDR-TB), mono-resistant(MR-TB), poly-resistant(PDR-TB), multidrug-resistant(MDR-TB), extensively drug-resistant(XDR-TB), and rifampicin-resistant (RR-TB) were 32.98% (505/1 531), 12.34% (189/1 531), 5.75% (88/1 531), 14.89% (228/1 531), 1.1% (17/1 531), 18.16% (278/1 531) respectively. The DR rate of different types in different areass were statistically different (P<0.05). The TDR-TB and RR-TB in retreated patients were higher than initial treated patients (χTDR2=505.00, P<0.01; χRR2=278.00, P<0.05). The resistance rates of six anti-tuberculosis drugs from high to low were INH, SM, RFP, EMB, OFX and KM. By the spectrum of mono-resistance, SM was the highest. By the spectrum of PDR-TB, 7 types were found and concurrently resistant to both INH and SM was the highest. By the spectrum of MDR-TB, 16 types were found and concurrently resistant to INH, RFP, SM and EMB was the highest. By population characteristics, the total drug-resistant rate in female was higher than male, in youth group was higher than middle and old age groups, in different minorities from high to low were Han, Hui, others and Tibetan were statistically different (P<0.05). The DR-TB of Qinghai Province is higher than the national level, which may be related to cold and hypoxia harsh environment, and limited medical resources for the diagnosing and treating drug-resistant tuberculosis. So the government's commitment should be fulfilled and detection and treatment of DR-TB should be strengthened, especially newly treated patients.
蒋明霞, 王兆芬, 马斌忠, 晁秀珍, 王蓉, 马永成, 张祖豪, 王朝才, 李尔琛, 魏於家, 李斌. 高海拔地区结核分枝杆菌耐药特征研究[J]. 中国人兽共患病学报, 2022, 38(3): 203-209.
JIANG Ming-xia, WANG Zhao-fen, MA Bin-zhong, CHAO Xiu-zhen, WANG Rong, MA Yong-cheng, ZHANG Zu-hao, WANG Chao-cai, LI Er-chen, WEI Yu-jia, LI Bin. Study on drug resistance of Mycobacterium tuberculosis circulating in high altitude area. Chinese Journal of Zoonoses, 2022, 38(3): 203-209.
2022, Vol. 38 
