Abstract：Tuberculosis (TB) is a chronic infectious disease caused by Mycobacterium tuberculosis infection, which results mainly in lung inflammation. This pathogen has existed for thousands of years in human history and severely endangers human health. TB remains a public health problem to be addressed. Its pathogenesis is complex and diverse, involving many aspects of genetic evolution and molecular biology. In recent years, research on the pathogenesis of TB has progressed, thus opening new directions for TB diagnosis and treatment, and vaccine research and development. This review focuses on immunologically associated genes, the variation and evolution of the Mycobacterium tuberculosis complex, the relationship between immunocytes and granuloma and TB, and the effects on host metabolism.
杜威, 刘春雨, 王路生, 何茂郎, 丁海涛, 代金鹏, 吴江东. 结核病发病机制的研究进展[J]. 中国人兽共患病学报, 2022, 38(3): 217-225.
DU Wei, LIU Chun-yu, WANG Lu-sheng, HE Mao-lang, DING Hai-tao, DAI Jin-peng, WU Jiang-dong. Research progress in the pathogenesis of tuberculosis. Chinese Journal of Zoonoses, 2022, 38(3): 217-225.
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