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Observation on experimental infection of macaque by cysticercus |
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Abstract ABSTRACT: The aim of this study was to understand liver function, ultrasonography and pathological changes of liver of the macaque with cysticercosis. A macaque was infected by eggs of T.solium through digestive tract. Color Doppler ultrasound examination, automatic biochemical analysis of some indicators of liver function, radioimmunoassay of hyaluronic acid and ELISA of anti-cysticercus IgG in sera were carried on the macaque which had been infected for 84 days. Euthanasia was carried on the macaque by injection of excessive anesthetic at 90 days after infection. Distribution and development of the larvae in macaques’ tissue and pathological changes were observed. Results showed that the macaque lost weight of 2.4 kg after
been infected by T.solium larvae for 84 days, and several nodules on the liver could be found by color Doppler ultrasound examination. Concentration of hyaluronic acid and total bile acid were higher than that of the pre-infection sample, whereas the concentration of choline esterase was lower. ELISA of anti-cysticercus was positive.11 nodules were found in the liver tissue by gross examination. Eosinophil infiltration, local fibrosis, fatty change and necrosis of hepatic cells could be found in the liver. This study suggested that beside muscle and brain cysticercosis,T.solium larvae could also invade the liver of primate and lead to hepatic lesions. The hepatic lesions could be diagnosed by ultrasound examination and immunology method.
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Received: 04 March 2011
Published: 27 October 2011
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Corresponding Authors:
Zheng-Hong ZHEN
E-mail: joeanchenhan@hotmail.com
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