|
|
|
| Inhibition of prion replication by ferulic acid |
| BAI Huan-li1, 2, ZHANG Hai-lei1, 2, JU Chuan-jing2, 3, MENG Ke-yin2,
LI Zhong-yi2, YANG Peng2, 4, XU Jing2, WAN Jia-yu2, SHEN Hai-qing1 |
1.College of Animal Science and Veterinary Medicine, Jilin University, Changchun 130062, China;
2.Military Veterinary Institute, Academy of Military Medical Sciences of PLA, Changchun 130062, China;
3.The Fourth Hospital of Jilin University, Changchun 130110, China;
4.Animal Husbandry Bureau of Hunchun, Hunchun 133300, China |
|
|
|
|
Abstract In this study, we explored the role of ferulic acid on prion replication by established scrapie-infected mouse neuroblastoma cells (ScN2a). Western blot analysis of PK-digested PrP(Sc) revealed the role of ferulic acid on prion replication. The results showed that 0.5, 1 and 5 g/mL of ferulic acid could significantly inhibit PrPSc formation (P<0.01). Ferulic acid, a Chinese medicine monomer, could inhibit PrPSc replication. We conclude that ferulic acid may play a role in the treatment of prion diseases, which provides a new idea for the treatment of prion in the future.
|
|
Received: 08 May 2013
|
|
|
|
Corresponding Authors:
Wang Jia-yu,Email:wanjiayu@hotmail.com
E-mail: wanjiayu@hotmail.com
|
|
|
|
[1] Prusiner SB. Novel proteinaceous infectious particles cause scrapie[J]. Science, 1982, 216: 136-144.
[2]Srinivasan M, Sudheer AR, Menon VP. Ferulic acid: therapeutic potential through its antioxidant property[J]. J Clin Biochem Nutr, 2007, 40: 92-100. DOI: 10.3164/jcbn.40.92
[3]Cheng CY, Su SY, Tang NY, et al. Ferulic acid provides neuroprotection against oxidative stress-related apoptosis after cerebral ischemia/reperfusion injury by inhibiting ICAM-1 mRNA expression in rats[J]. Brain Res, 2008, 1209: 136-150. DOI: 10.1016/j.brainres.2008.02.090
[4]Cheng CY, Su SY, Tang NY, et al. Ferulic acid inhibits nitric oxide-induced apoptosis by enhancing GABAB1 receptor expression in transient focal cerebral ischemia in rats[J]. Acta Pharmacol Sin, 2010, 31: 889-899. DOI: 10.1038/aps.2010.66
[5]Koh PO. Ferulic acid prevents the cerebral ischemic injury-induced decrease of Akt and Bad phosphorylation[J]. Neurosci Lett, 2012, 507: 156-160. DOI: 10.1016/j.neulet.2011.12.012
[6]Yabe T, Hirahara H, Harada N, et al. Ferulic acid induces neural progenitor cell proliferation in vitro and in vivo[J]. Neuroscience, 2010, 165: 515-524. DOI: 10.1016/j.neuroscience.2009.10.023
[7]Mori T, Koyama N, Guillot-Sestier MV, et al. Ferulic acid is a nutraceuticalβ-secretase modulator that improves behavioral impairment and alzheimer-like pathology in transgenic mice[J]. PloS One, 2013, 8(2): e55774. DOI: 10.1371/journal.pone.0055774
[8]Cronier S, Gros N, Tattum MH, et al. Detection and characterization of proteinase K sensitive disease-related prion protein with thermolysin[J]. Biochem J, 2008, 416: 297-305. DOI: 10.1042/BJ20081235 |
| [1] |
DONG Jian-hua, WANG Li, SHI Wei, LI Shen, WEI Jing, ZHENG Yuan, YU Peng-bo, MENG Yao, XU Yi. Characteristics of Creutzfeldt-Jakob disease cases in Shaanxi Province,China,2011-2015[J]. Chinese Journal of Zoonoses, 2017, 33(11): 1013-1017. |
|
|
|
|
2013, Vol. 29 
