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| Expression and prognostic value of T cell immunoglobulin mucin in patients with severe pulmonary tuberculosis |
| WU Duo-chi1, ZHONG Ye-teng2, WANG Yu-feng3, WU Ye-ying1, ZHAO Qing-zhu1 |
1. Haikou Affiliated Hospital of Central South University Xiangya School of Medicine,Haikou 570208,China;
2. The Second Affiliated Hospital of Hainan Medical University,Haikou 570311,China;
3. Beijing Chest Affiliated Hospital of Capital Medical University, Beijing 101100,China |
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Abstract This study aimed to investigate the expression and prognostic value of T lymphocyte subsets, T cell immunoglobulin mucin molecule (TIM-1 and TIM-3) in patients with severe pulmonary tuberculosis. A total of 1 056 patients with severe pulmonary tuberculosis treated in our hospital from January 2019 to June 2021 were analyzed retrospectively and defined as the severe pulmonary tuberculosis group. A total of 1 000 patients with mild pulmonary tuberculosis treated in our hospital in the same period were selected as the mild pulmonary tuberculosis group. The levels of TIM-1, TIM-3 and peripheral blood T cell subsets (CD4+ and CD8+) were compared between groups. The mRNA levels of TIM-1 and TIM-3 in peripheral blood mononuclear cells were detected and compared. The relationships among TIM-1, TIM-3 and peripheral blood T cell subsets and prognosis in patients with severe pulmonary tuberculosis were assessed. The levels of CD8+, TIM-1 and TIM-3 in the severe pulmonary tuberculosis group were higher than those in the mild pulmonary tuberculosis group, and the level of CD4+ was lower than that in the mild pulmonary tuberculosis group (all P<0.001). The levels of TIM-1 mRNA and TIM-3 mRNA in the severe pulmonary tuberculosis group were higher than those in the mild pulmonary tuberculosis group (all P<0.001). The levels of CD8+, TIM-1 and TIM-3 in the death group were higher than those in the survival group, and the level of CD4+ was lower than that in the survival group (all P<0.001). TIM-1 and TIM-3 were negatively correlated with CD4+ (r=-0.114, r=-0.211, P<0.05) but positively correlated with CD8+ (r=0.571, r=0.680, P<0.05). The immune dysfunction in patients with severe pulmonary tuberculosis may be related to the abnormal levels of T cell subsets in peripheral blood and the elevated expression of TIM-1 and TIM-3.
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Received: 27 October 2021
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| Fund:Supported by the Hainan Provincial Natural Science Foundation (No.820MS144) |
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Corresponding Authors:
Wu Duo-chi, Email: 1575256296@qq.com
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2022, Vol. 38 
