Fund:Supported by the National Natural Science Foundation of China (Nos. 81172790 and 81671586), and the Academic and Technical Leaders of Wannan Medical College (No. 010202041703)
Abstract
Allergen-specific immunotherapy (ASIT) is the only treatment that causes a long-lasting relief of symptoms and change the natural course at this stage. This treatment has been widely applied in allergic diseases and achieved successful clinical outcomes. With the development of treatment, ASIT demonstrated unparalleled advantages of allergic diseases. This review summarizes the advances in the mechanisms of ASIT, the application of drug and route of administration to provide a reference for ASIT.
BeasleyR. The burden of asthma with specific reference to the United States[J]. , 2002, 109(5 Suppl): S482-489. DOI: 10.1067/mai.2002.122716[本文引用:1]
[2]
AsherMI, MontefortS, BjorkstenB, et al. Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys[J]. , 2006, 368(9537): 733-743. DOI: 10.1016/S0140-6736(06)69283-0[本文引用:1]
[3]
LewkowichIP, LajoieS, ClarkJR, et al. Allergen uptake, activation, and IL-23 production by pulmonary myeloid DCs drives airway hyperresponsiveness in asthma-susceptible mice[J]. , 2008, 3(12): e3879. DOI: 10.1371/journal.pone.0003879[本文引用:1]
[4]
VargasMH, Diaz-MejiaGS, FuruyaME, et al. Trends of asthma in Mexico: an 11-year analysis in a nationwide institution[J]. , 2004, 125(6): 1993-1997. DOI: 10.1378/chest.125.6.1993[本文引用:1]
[5]
GalliSJ, TsaiM, PiliponskyAM. The development of allergic inflammation[J]. , 2008, 454(7203): 445-454. DOI: 10.1038/nature07204[本文引用:2]
[6]
RachmielM, BlochO, BistritzerT, et al. TH1/TH2 cytokine balance in patients with both type 1 diabetes mellitus and asthma[J]. , 2006, 34(3-4): 170-176. DOI: 10.1016/j.cyto.2006.04.012[本文引用:1]
[7]
YingL, FuZ, LuoJ, et al. Cytotoxic T lymphocyte antigen 4 immunoglobulin modified dendritic cells attenuate allergic airway inflammation and hyperresponsiveness by regulating the development of T helper type 1 (Th1)/Th2 and Th2/regulatory T cell subsets in a murine model of asthma[J]. , 2011, 165(1): 130-139. DOI: 10.1111/j.1365-2249.2011.04405.x[本文引用:1]
[8]
SiwiecJ, ZaborowskiT, JankowskaO, et al. Evaluation of Th1/Th2 lymphocyte balance and lipopolysaccharide receptor expression in asthma patients[J]. , 2009, 77(2): 123-130. [本文引用:2]
[9]
SimoesDC, PsarraAM, MauadT, et al. Glucocorticoid and estrogen receptors are reduced in mitochondria of lung epithelial cells in asthma[J]. , 2012, 7(6): e39183. DOI: 10.1371/journal.pone.0039183[本文引用:1]
[10]
KeenanCR, SalemS, FietzER, et al. Glucocorticoid-resistant asthma and novel anti-inflammatory drugs[J]. , 2012, 17(17-18): 1031-1038. DOI: 10.1016/j.drudis.2012.05.011[本文引用:1]
[11]
BenedictisFM, CarloniI. Safety of long-acting beta2-agonists in asthma[J]. , 2012, 67(11): 1014-1015. DOI: 10.1136/thoraxjnl-2012-201991[本文引用:1]
[12]
Castro-RodriguezJA, RodrigoGJ. A systematic review of long-acting beta2-agonists versus higher doses of inhaled corticosteroids in asthma[J]. , 2012, 130(3): e650-657. DOI: 10.1542/peds.2012-0162[本文引用:1]
[13]
ImaiK, MunehisaY, YoshikuniY, et al. Influences of pyrexia and age on theophylline clearance in young children with asthma[J]. , 2012, 61(1): 15-18. [本文引用:1]
[14]
WangY, LinK, WangC, et al. Addition of theophylline or increasing the dose of inhaled corticosteroid in symptomatic asthma: a meta-analysis of rand omized controlled trials[J]. , 2011, 52(2): 268-275. DOI: 10.3349/ymj.2011.52.2.268[本文引用:1]
[15]
JacobsenL, WahnU, BiloMB. Allergen-specific immunotherapy provides immediate, long-term and preventive clinical effects in children and adults: the effects of immunotherapy can be categorised by level of benefit-the centenary of allergen specific subcutaneous immunotherapy[J]. , 2012, 2(13): 8-19. DOI: 10.1186/2045-7022-2-8[本文引用:1]
[16]
TillSJ, FrancisJN, Nouri-AriaK, et al. Mechanisms of immunotherapy[J]. , 2004, 113(6): 1025-1034. DOI: 10.1016/j.jaci.2004.03.024[本文引用:2]
[17]
BousquetJ, LockeyR, MallingHJ. Allergen immunotherapy: therapeutic vaccines for allergic diseases. A WHO position paper[J]. , 1998, 102(4 Pt 1): 558-562. DOI: 10.1111/j.1398-9995.1998.tb04930.x[本文引用:1]
FujitaH, SoykaMB, AkdisM, et al. Mechanisms of allergen-specific immunotherapy[J]. , 2012, 2(1): 2. DOI: 10.1186/2045-7022-2-2[本文引用:1]
[20]
MitsiasDI, SavvatianosS, PapadopoulosNG. An insight into the early mechanisms of allergen-specific immunotherapy[J]. , 2011, 3(3): 333-336. DOI: 10.2217/imt.10.112[本文引用:1]
MoverareR, ElfmanL, VesterinenE, et al. Development of new IgE specificities to allergenic components in birch pollen extract during specific immunotherapy studied with immunoblotting and Pharmacia CAP System[J]. , 2002, 57(5): 423-430. DOI: 10.1034/j.1398-9995.2002.13248.x[本文引用:1]
[28]
GovindarajD, GaurSN, AroraN. Characterization of recombinant Per a 10from Periplaneta americana[J]. , 2013, 20(2): 262-268. DOI: 10.1128/CVI.00461-12[本文引用:1]
[29]
MyrsetHR, BarlettaB, Di FeliceG, et al. Structural and Immunological Characterization of Recombinant Pan b 1, a Major Allergen of Northern Shrimp, Pand alus borealis[J]. , 2012, 160(3): 221-232. DOI: 10.1159/000339740[本文引用:1]
[30]
Bordas-Le FlochV, BussieresL, AiroucheS, et al. Expression and characterization of natural-like recombinant Der p 2 for sublingual immunotherapy[J]. , 2012, 158(2): 157-167. DOI: 10.1159/000331143[本文引用:1]
GafvelinG, ParmleyS, Neimert-AnderssonT, et al. Hypoallergens for allergen-specific immunotherapy by directed molecular evolution of mite group 2 allergens[J]. , 2007, 282(6): 3778-3787. DOI: 10.1074/jbc.M607938200[本文引用:1]
[33]
WallnerM, StocklingerA, ThalhamerT, et al. Allergy multivaccines created by DNA shuffling of tree pollen allergens[J]. , 2007, 120(2): 374-380. DOI: 10.1016/j.jaci.2007.05.021[本文引用:1]
[34]
ScheiblhoferS, StoecklingerA, GruberC, et al. Gene gun immunization with clinically relevant allergens aggravates allergen induced pathology and is contraindicated for allergen immunotherapy[J]. , 2007, 44(8): 1879-1887. DOI: 10.1016/j.molimm.2006.09.023[本文引用:1]
[35]
LiG, LiuZ, ZhongN, et al. Therapeutic effects of DNA vaccine on allergen-induced allergic airway inflammation in mouse model[J]. , 2006, 3(5): 379-384. DOI: 10.1016/j.cellimm.2006.05.009[本文引用:1]
[36]
HartlA, HochreiterR, StepanoskaT, et al. Characterization of the protective and therapeutic efficiency of a DNA vaccine encoding the major birch pollen allergen Bet v 1a[J]. , 2004, 59(1): 65-73. DOI: 10.1046/j.1398-9995.2003.00335.x[本文引用:1]
[37]
WangY, QianG, WangG, et al. Potential therapy of Fc-antigen combination-encoding DNA vaccination in mouse allergic airway inflammation[J]. , 2008, 154(1): 115-122. DOI: 10.1111/j.1365-2249.2008.03736.x[本文引用:1]
[38]
LarcheM. Immunoregulation by targeting T cells in the treatment of allergy and asthma[J]. , 2006, 18(6): 745-750. DOI: 10.1016/j.coi.2006.09.013[本文引用:1]
[39]
NiederbergerV, HorakF, VrtalaS, et al. Vaccination with genetically engineered allergens prevents progression of allergic disease[J]. , 2004, 101Suppl 2: 14677-14682. DOI: 10.1073/pnas.0404735101[本文引用:1]
[40]
JutelM, JaegerL, SuckR, et al. Allergen-specific immunotherapy with recombinant grass pollen allergens[J]. , 2005, 116(3): 608-613. DOI: 10.1016/j.jaci.2005.06.004[本文引用:1]
[41]
KundigTM, SentiG, SchnetzlerG, et al. Der p 1 peptide on virus-like particles is safe and highly immunogenic in healthy adults[J]. , 2006, 117(6): 1470-1476. DOI: 10.1016/j.jaci.2006.01.040[本文引用:1]
EspositoS, DalenoC, PicciolliI, et al. Immunogenicity and safety of intradermal influenza vaccine in children[J]. , 2011, 29(44): 7606-7610. DOI: 10.1016/j.vaccine.2011.08.021[本文引用:1]
[44]
FleischerDM, BurksAW, VickeryBP, et al. Sublingual immunotherapy for peanut allergy: A rand omized, double-blind, placebo-controlled multicenter trial[J]. , 2013, 131(1): 119-127. DOI: 10.1016/j.jaci.2012.11.011[本文引用:1]
[45]
YamadaT, TonguM, GodaK, et al. Sublingual Immunotherapy Induces Regulatory Function of IL-10-Expressing CD4(+)CD25(+)Foxp3(+) T Cells of Cervical Lymph Nodes in Murine Allergic Rhinitis Model[J]. , 2012, 2012: 490905. DOI: 10.1155/2012/490905[本文引用:1]
[46]
TodaM, KasaiM, HosokawaH, et al. DNA vaccine using invariant chain gene for delivery of CD4+ T cell epitope peptide derived from Japanese cedar pollen allergen inhibits allergen-specific IgE response[J]. , 2002, 32(6): 1631-1639. DOI: 10.1002/1521-4141(200206)32:6<1631::AID-IMMU1631>3.0.CO;2-O[本文引用:1]
[47]
JohansenP, HaffnerAC, KochF, et al. Direct intralymphatic injection of peptide vaccines enhances immunogenicity[J]. , 2005, 35(2): 568-574. DOI: 10.1002/eji.200425599[本文引用:1]
[48]
CoxL, NelsonH, LockeyR, et al. Allergen immunotherapy: a practice parameter third update[J]. , 2011, 127(1 Suppl): S1-55. DOI: 10.1016/j.jaci.2010.09.034[本文引用:1]
[49]
LangDM, AlpernMB, VisintainerPF, et al. Elevated risk of anaphylactoid reaction from radiographic contrast media is associated with both beta-blocker exposure and cardiovascular disorders[J]. , 1993, 153(17): 2033-2040. DOI: 10.1001/archinte.1993.00410170119012[本文引用:1]